Tough to compare to an animated series. They were awesome but how many episodes do you specifically remember? To this day I still quote and reference Rugrats. Could also almost do an entire one for Nick game shows.
Pete and Pete should be an option as well. Randomly watched the nightcrawler episode the other night. It's amazing how great that show was.
this list is useless without Ren & Stimpy mine are: Ren & Stimpy Salute Your Shorts Are You Afraid of the Dark?