COVID-19 info thread

Discussion in 'The Mainboard' started by TrustyPatches, Mar 15, 2020.

  1. Jay Jay Okocha

    Donor

  2. Room 15

    Room 15 Mi equipo esta Los Tigres
    Donor
    Auburn TigersAtlanta BravesAtlanta FalconsAtlanta UnitedUnited States Men's National Soccer TeamLiverpool

    We’re back!
     
    Biship and BWC like this.
  3. Lyrtch

    Lyrtch My second favorite meat is hamburger
    Staff Donor

    lmbo
     
  4. Jay Jay Okocha

    Donor

    Why? He's very interesting, not a crank by any means.
     
  5. Lyrtch

    Lyrtch My second favorite meat is hamburger
    Staff Donor

    the vitamin d thing has been discussed in here a bunch
     
    Eamudo229 likes this.
  6. Jay Jay Okocha

    Donor

    Ya I bet, but there is some more up to date studies in there that he references. He's a good watch generally.
     
  7. Redav

    Redav My favorite meat is hotdog
    Donor

    Lol we're back on taking vitamin d?
     
  8. HatterasJack

    HatterasJack Is your refrigerator running? It's Mike Hunt.
    Donor

    Dear fucking lord
     
    cutig likes this.
  9. RonBurgundy

    RonBurgundy Well-Known Member

    There is nothing wrong with taking vit D. There’s lots of potential benefits to having normal vitamin D levels.

    BUT - sick and old and chronically unhealthy people have low vitamin D, especially in the United States.

    so when researchers say “what health issues might be related to Vitamin D??” They literally can see a relation to literally almost every chronic disease. When they study vitamin D replacement in placebo controlled RCTs, nothing usually happens to these conditions.

    regarding his linked meta analysis, I went and actually read through it over lunch. The claimed Meta analysis says taking vitamin D will prevent URIs. Of the 25 RCTs in the analysis, only 8 actually are statistically significant and 17 show it isn’t helpful. When adding up all of them, there’s a 12% reduction In risk of getting a URI that’s not even statistically significant until you look into subgroup analysis of the data. Quote from the article (Figure 4 from the meta analysis FYI)
    . So while there may be a benefit to vitamin D replacement on the immune system and preventing the likelihood of a URI, even the data supporting it is incredibly weak and small enough to not be clinically significant in the majority of studies and only significant when piles of negative studies are mixed in with crazy outlier positive studies and even then the results look mixed to slight improvement.

    so, for the billionth time since Science has started to investigate Vit D and non-skeletal health impacts: sure it’s probably playing a role, albeit a small one. Supplement if you don’t get enough sun to protect your bone health, but overall doesn’t matter a ton in the long run. Young and Healthy people have better vit D than unhealthy and older people, and taking vit D supplements doesn’t lower mortality rates, according to about a jillion studies on the topic.
     
    Uncle Si, The Banks, IV and 21 others like this.
  10. Room 15

    Room 15 Mi equipo esta Los Tigres
    Donor
    Auburn TigersAtlanta BravesAtlanta FalconsAtlanta UnitedUnited States Men's National Soccer TeamLiverpool

    Still hating.
     
    Uncle Si, IV and RonBurgundy like this.
  11. Illinihockey

    Illinihockey Well-Known Member
    Chicago CubsChicago BullsChicago BearsChicago BlackhawksIllinois Fightin' IlliniLiverpool

    If there’s a workable vaccine announced in mid-late December what does that mean practically? 100 million doses ready to distribute by the end of January? Less? More?
     
  12. RonBurgundy

    RonBurgundy Well-Known Member

    I got burned very early in my career by this. Was with a preceptor when I was in Med school who was convinced that statin related myopathy was caused by vit D deficiency (as seen in observation trials there may be a link). So I was going to do an M4 research project on it, and had a mentor basically laugh in my face and so began my indoctrination into hating on Vit D research.
     
  13. Lyrtch

    Lyrtch My second favorite meat is hamburger
    Staff Donor

    Matters which vaccine.
     
  14. Illinihockey

    Illinihockey Well-Known Member
    Chicago CubsChicago BullsChicago BearsChicago BlackhawksIllinois Fightin' IlliniLiverpool

    then say Moderna or whichever one the US is partnering with
     
  15. slogan119

    slogan119 Her?
    Donor TMB OG
    Florida State SeminolesChicago CubsReal Madrid

    I’m seriously tired of trying to combat propaganda. Almost to the point where my retort is going to be “Welp, if you die, you die” and just move on.

    Fuck these people who see wearing a mask as anything other than a minor inconvenience.
     
  16. Room 15

    Room 15 Mi equipo esta Los Tigres
    Donor
    Auburn TigersAtlanta BravesAtlanta FalconsAtlanta UnitedUnited States Men's National Soccer TeamLiverpool

    US has a contract with Pfizer for 100 million doses to be delivered by December I think.
     
  17. THF

    THF BITE THE NUTS, THUMB IN THE ASS!
    Donor
    Arkansas RazorbacksSan Francisco GiantsOklahoma City ThunderDallas CowboysSan Francisco 49'ersMontreal Impact

    I think there are a lot of components which go in to the answer for this question.

    In June, Moderna stated they expected to be able to produce around 1 Bil doses in a year. - https://www.axios.com/moderna-coron...ion-39d60497-1715-405e-9169-f4d334b6a833.html

    It looks like they have partnered with Catalent to act as a vaccine manufacturing partner - https://www.fiercepharma.com/manufa...l-finish-duties-for-covid-19-vaccine-prospect

    I think Pfizer is already manufacturing their vaccine with the anticipation that it will be approved and used and they expect to have 100 mil doses ready by end of 2020. I doubt Moderna will be able to match Pfizer's pace given the challenges of a new supply chain setup and ramp speed. I expect they will start delivering substantial quantities in 2021.

    Its already being discussed but then you have to identify who those first 100 mil doses go to? Of course I would expect it would be given to front line workers and healthcare workers. But as the government is funding some of this, I expect they would be vaccinating a large percentage of the military as a precautionary measure which I have not heard mentioned much. I have no source on this, just would make sense to me. Following that, I would expect the higher risked individuals to receive it.

    So for healthy younger population we may be looking at waiting until 2021 for available doses.
     
    One Two likes this.
  18. One Two

    One Two Send it!
    Donor
    Auburn TigersAtlanta Braves

    In the interest of approaching herd protection ideally the first people to receive the vaccine would be essential and frontline/first responder types that can’t avoid human contact as this would be the fastest track to lower transmission with less than an ideal number of doses
     
  19. Biship

    Biship Well-Known Member
    Donor
    Kansas State WildcatsKansas City RoyalsKansas City ChiefsSporting Kansas City

    Does taking vitamin d get you out of poverty?
     
    IV likes this.
  20. Jay Jay Okocha

    Donor

    Not at all. I find it interesting to learn from all experts on this stuff. I like Dr John’s explanations and opinions of these things as a layman & he is talking about new research from this month, he is faaaar from a contrarian on Covid, just talks about interesting things. Good post too Ron. :heythere:
     
  21. RonBurgundy

    RonBurgundy Well-Known Member

    Holy shit, that’s amazing to see and not surprising given influenza less contagious and deadly than Covid.
    Yeah he’s not a crank or a crack pot. It’s pretty easy to see that vit D levels can often be a pretty good surrogate for general health in some people, but too often it’s just correlated with age and comorbidities. His comment about the US having a vitamin D crisis is only half wrong, we have a metabolic crisis in our country that’s a combination of no outside exercise (and thereby less vit D) and shitty dietary habits that make people chronically ill.

    unfortunately, supplementing with Vit D might make a lab look better and make you 5% healthier (never a bad thing), but misses the rest of the picture.

    so he’s not wrong, there’s just a shitload more to the story about what’s wrong with America’s health.
     
    NYGator, slogan119, BWC and 1 other person like this.
  22. pperc

    pperc Well-Known Member
    Donor

    supplements, although cheap, are big business.
     
    IV likes this.
  23. Room 15

    Room 15 Mi equipo esta Los Tigres
    Donor
    Auburn TigersAtlanta BravesAtlanta FalconsAtlanta UnitedUnited States Men's National Soccer TeamLiverpool

    Don't lay up on Ron!

    He hasn't even posted a picture of his degree yet...
     
    IV likes this.
  24. RonBurgundy

    RonBurgundy Well-Known Member

    Oh fuuuuuuuuck

    https://jamanetwork.com/journals/jamacardiology/fullarticle/2768916

    (caveat to study: super high, non representative of total cases by percentage of hospitalized patients and symptomatic patients)
     
  25. pperc

    pperc Well-Known Member
    Donor

    IV and One Two like this.
  26. Pile Driving Miss Daisy

    Pile Driving Miss Daisy It angries up the blood
    Donor
    Texas LonghornsAtlanta BravesAtlanta HawksAtlanta FalconsAtlanta UnitedGeorgia Southern Eagles

    It says they got the data from University Hospital Frankfurt, but were these all people who required hospitalization?
     
  27. pnk$krtcrÿnästÿ

    Donor
    Rutgers Scarlet KnightsArizona WildcatsTexas AandM Aggies altTennessee Volunteers

    they said vitamin D did what now?

    Nevermind it doesn't matter vitamin D has some weird David Koresh type of manipulative psycho-spiritual power over a bunch of doctors the world over. Vitamin D is getting their wives pregnant.
     
  28. RonBurgundy

    RonBurgundy Well-Known Member

    There’s a pretty decent correlation between people who get muscle aches from statins and low Vit D. My study design was going to be small randomized trial of statin intolerant patients but doing 3 months of Vit D replacement vs placebo before restarting statin and seeing if there was a difference in reported muscle aches
     
    One Two likes this.
  29. RonBurgundy

    RonBurgundy Well-Known Member

    33% had been hospitalized
     
    One Two likes this.
  30. Room 15

    Room 15 Mi equipo esta Los Tigres
    Donor
    Auburn TigersAtlanta BravesAtlanta FalconsAtlanta UnitedUnited States Men's National Soccer TeamLiverpool

    I think you should do the study now. On weekends. Show that asshole professor who’s boss.
     
  31. AHebrewToo

    AHebrewToo Albino Hebrew Extraordinaire
    Donor
    Indiana HoosiersNotre Dame Fighting IrishWashington NationalsIndiana PacersIndianapolis Colts

  32. Arrec Bardwin

    Arrec Bardwin He ain’t me, he can’t be me
    Donor
    Auburn TigersAtlanta BravesAtlanta FalconsChelseaAtlanta United

    Abed proved empirically that Angela, is in fact, the boss.
     
  33. Can I Spliff it

    Can I Spliff it Is Butterbean okay?
    Donor

    feel free to put it at 1.5 speed
     
    xec and NYGator like this.
  34. Pile Driving Miss Daisy

    Pile Driving Miss Daisy It angries up the blood
    Donor
    Texas LonghornsAtlanta BravesAtlanta HawksAtlanta FalconsAtlanta UnitedGeorgia Southern Eagles

    Great so we're going to have thousands of people die from heart attacks or heart disease even after we get this completely under control? Seems scary
     
  35. zeberdee

    zeberdee wheel snipe celly boys
    Donor TMB OG
    Penn State Nittany LionsPhiladelphia PhilliesPhiladelphia 76'ersPhiladelphia EaglesPhiladelphia FlyersArsenalPhiladelphia UnionUnited States Men's National Soccer Team

    I apologize as I’m sure it’s been covered, but how bad is that Verum Tota shit I keep seeing? a bunch of “doctors” talking about a cure. being spread by Breitbart mostly it looks like.

    it’s so depressing how many people eat it up.
     
  36. pperc

    pperc Well-Known Member
    Donor

    There is probably a genetic component
     
  37. IV

    IV I'm often wrong, but occasionally correct
    Donor TMB OG
    Alabama Crimson TideCollege Football PlayoffAvengers

  38. angus

    angus Well-Known Member
    Donor

    Can't get any info on Google outside of a podcast or Facebook. Not a good sign of reliable information.
     
  39. zeberdee

    zeberdee wheel snipe celly boys
    Donor TMB OG
    Penn State Nittany LionsPhiladelphia PhilliesPhiladelphia 76'ersPhiladelphia EaglesPhiladelphia FlyersArsenalPhiladelphia UnionUnited States Men's National Soccer Team

    oh I know it’s not reliable just curious how bad it is from
    a scientific standpoint. if anyone I care about starts telling me about it I’d like to be able to wet them straight as quickly as possible.
     
  40. xec

    xec Well-Known Member
    Donor
    Florida State SeminolesUtah UtesReal Salt LakeLas Vegas Golden KnightsPorto

    The Trumpers will say the presentation proves that CDC has been lying the whole time. This, even though their data clearly showed blue states were doing much worse than red states for quite a while. If they were lying they wouldn’t have shown that.
     
  41. HotMic

    HotMic Mr So-and-So
    Donor
    Ohio State BuckeyesCleveland BrownsKent State Golden FlashesCleveland CavaliersCleveland IndiansGame of Thrones

    Told my wife she needs more vitamin D.

    :gfa:
     
  42. billdozer

    billdozer Well-Known Member
    Donor
    Clemson TigersCarolina Panthers

    How long did she laugh for?
     
  43. pperc

    pperc Well-Known Member
    Donor

    ivermectin making the rounds again..
     
    RonBurgundy likes this.
  44. HatterasJack

    HatterasJack Is your refrigerator running? It's Mike Hunt.
    Donor

    The standard 15 seconds.
     
  45. HotMic

    HotMic Mr So-and-So
    Donor
    Ohio State BuckeyesCleveland BrownsKent State Golden FlashesCleveland CavaliersCleveland IndiansGame of Thrones

    Hmm, I don’t remember her laughing. She invited some guy friends over today and said she’d be busy for awhile. I’ll give her a ring and check in a bit to see if she thought it was funny.
     
  46. RonBurgundy

    RonBurgundy Well-Known Member

    Hasn’t been ruled out yet!

    also anecdote time, but a buddy of mine is a small town, rural family Doc and his town is being hit for the first time. There were several massive 4th of July lake house parties and a bunch of infected high school and college kids (back in town for summer) spread it around, and then spread to families. Several of those adults work at the local nursing home.

    The town has about 1500 people, and now there’s about ~100 confirmed positives from these parties and 10 Covid positive nursing home deaths, and several of them have been sudden, unexplained nursing home deaths in their sleep (probably clots or strokes if I had to guess).

    anecdotal evidence but this is the nightmare scenario that isn’t hard to see happening.
     
  47. xec

    xec Well-Known Member
    Donor
    Florida State SeminolesUtah UtesReal Salt LakeLas Vegas Golden KnightsPorto

    Related to this, on July 4 I marked my calendar for today to see if any case spikes or hot spots are beginning to emerge. Based on your post it looks like there are places where the case spike probably began sooner if there are already deaths being reported.
     
  48. Room 15

    Room 15 Mi equipo esta Los Tigres
    Donor
    Auburn TigersAtlanta BravesAtlanta FalconsAtlanta UnitedUnited States Men's National Soccer TeamLiverpool

    bertwing, THF and One Two like this.
  49. RonBurgundy

    RonBurgundy Well-Known Member

    Wait, people don’t know that I make medicine out of alien dna and that demon sperm causes endometriosis?

    lol what simpletons you guys are. Sorry, snowflakes.