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Discussion in 'The Mainboard' started by TrustyPatches, Mar 15, 2020.
Why? He's very interesting, not a crank by any means.
the vitamin d thing has been discussed in here a bunch
Ya I bet, but there is some more up to date studies in there that he references. He's a good watch generally.
Lol we're back on taking vitamin d?
Dear fucking lord
There is nothing wrong with taking vit D. There’s lots of potential benefits to having normal vitamin D levels.
BUT - sick and old and chronically unhealthy people have low vitamin D, especially in the United States.
so when researchers say “what health issues might be related to Vitamin D??” They literally can see a relation to literally almost every chronic disease. When they study vitamin D replacement in placebo controlled RCTs, nothing usually happens to these conditions.
regarding his linked meta analysis, I went and actually read through it over lunch. The claimed Meta analysis says taking vitamin D will prevent URIs. Of the 25 RCTs in the analysis, only 8 actually are statistically significant and 17 show it isn’t helpful. When adding up all of them, there’s a 12% reduction In risk of getting a URI that’s not even statistically significant until you look into subgroup analysis of the data. Quote from the article (Figure 4 from the meta analysis FYI)
. So while there may be a benefit to vitamin D replacement on the immune system and preventing the likelihood of a URI, even the data supporting it is incredibly weak and small enough to not be clinically significant in the majority of studies and only significant when piles of negative studies are mixed in with crazy outlier positive studies and even then the results look mixed to slight improvement.
so, for the billionth time since Science has started to investigate Vit D and non-skeletal health impacts: sure it’s probably playing a role, albeit a small one. Supplement if you don’t get enough sun to protect your bone health, but overall doesn’t matter a ton in the long run. Young and Healthy people have better vit D than unhealthy and older people, and taking vit D supplements doesn’t lower mortality rates, according to about a jillion studies on the topic.
If there’s a workable vaccine announced in mid-late December what does that mean practically? 100 million doses ready to distribute by the end of January? Less? More?
I got burned very early in my career by this. Was with a preceptor when I was in Med school who was convinced that statin related myopathy was caused by vit D deficiency (as seen in observation trials there may be a link). So I was going to do an M4 research project on it, and had a mentor basically laugh in my face and so began my indoctrination into hating on Vit D research.
Matters which vaccine.
then say Moderna or whichever one the US is partnering with
I’m seriously tired of trying to combat propaganda. Almost to the point where my retort is going to be “Welp, if you die, you die” and just move on.
Fuck these people who see wearing a mask as anything other than a minor inconvenience.
US has a contract with Pfizer for 100 million doses to be delivered by December I think.
I think there are a lot of components which go in to the answer for this question.
In June, Moderna stated they expected to be able to produce around 1 Bil doses in a year. - https://www.axios.com/moderna-coron...ion-39d60497-1715-405e-9169-f4d334b6a833.html
It looks like they have partnered with Catalent to act as a vaccine manufacturing partner - https://www.fiercepharma.com/manufa...l-finish-duties-for-covid-19-vaccine-prospect
I think Pfizer is already manufacturing their vaccine with the anticipation that it will be approved and used and they expect to have 100 mil doses ready by end of 2020. I doubt Moderna will be able to match Pfizer's pace given the challenges of a new supply chain setup and ramp speed. I expect they will start delivering substantial quantities in 2021.
Its already being discussed but then you have to identify who those first 100 mil doses go to? Of course I would expect it would be given to front line workers and healthcare workers. But as the government is funding some of this, I expect they would be vaccinating a large percentage of the military as a precautionary measure which I have not heard mentioned much. I have no source on this, just would make sense to me. Following that, I would expect the higher risked individuals to receive it.
So for healthy younger population we may be looking at waiting until 2021 for available doses.
In the interest of approaching herd protection ideally the first people to receive the vaccine would be essential and frontline/first responder types that can’t avoid human contact as this would be the fastest track to lower transmission with less than an ideal number of doses
Does taking vitamin d get you out of poverty?
Not at all. I find it interesting to learn from all experts on this stuff. I like Dr John’s explanations and opinions of these things as a layman & he is talking about new research from this month, he is faaaar from a contrarian on Covid, just talks about interesting things. Good post too Ron.
Holy shit, that’s amazing to see and not surprising given influenza less contagious and deadly than Covid.
Yeah he’s not a crank or a crack pot. It’s pretty easy to see that vit D levels can often be a pretty good surrogate for general health in some people, but too often it’s just correlated with age and comorbidities. His comment about the US having a vitamin D crisis is only half wrong, we have a metabolic crisis in our country that’s a combination of no outside exercise (and thereby less vit D) and shitty dietary habits that make people chronically ill.
unfortunately, supplementing with Vit D might make a lab look better and make you 5% healthier (never a bad thing), but misses the rest of the picture.
so he’s not wrong, there’s just a shitload more to the story about what’s wrong with America’s health.
supplements, although cheap, are big business.
Don't lay up on Ron!
He hasn't even posted a picture of his degree yet...
(caveat to study: super high, non representative of total cases by percentage of hospitalized patients and symptomatic patients)
Ongoing cardiac inflammation bad
It says they got the data from University Hospital Frankfurt, but were these all people who required hospitalization?
they said vitamin D did what now?
Nevermind it doesn't matter vitamin D has some weird David Koresh type of manipulative psycho-spiritual power over a bunch of doctors the world over. Vitamin D is getting their wives pregnant.
There’s a pretty decent correlation between people who get muscle aches from statins and low Vit D. My study design was going to be small randomized trial of statin intolerant patients but doing 3 months of Vit D replacement vs placebo before restarting statin and seeing if there was a difference in reported muscle aches
33% had been hospitalized
I think you should do the study now. On weekends. Show that asshole professor who’s boss.
Tony Danza is boss.
Abed proved empirically that Angela, is in fact, the boss.
feel free to put it at 1.5 speed
Great so we're going to have thousands of people die from heart attacks or heart disease even after we get this completely under control? Seems scary
I apologize as I’m sure it’s been covered, but how bad is that Verum Tota shit I keep seeing? a bunch of “doctors” talking about a cure. being spread by Breitbart mostly it looks like.
it’s so depressing how many people eat it up.
There is probably a genetic component
Rachel is it so hard to put ineffective in the headline
Can't get any info on Google outside of a podcast or Facebook. Not a good sign of reliable information.
oh I know it’s not reliable just curious how bad it is from
a scientific standpoint. if anyone I care about starts telling me about it I’d like to be able to wet them straight as quickly as possible.
The Trumpers will say the presentation proves that CDC has been lying the whole time. This, even though their data clearly showed blue states were doing much worse than red states for quite a while. If they were lying they wouldn’t have shown that.
Told my wife she needs more vitamin D.
How long did she laugh for?
ivermectin making the rounds again..
The standard 15 seconds.
Hmm, I don’t remember her laughing. She invited some guy friends over today and said she’d be busy for awhile. I’ll give her a ring and check in a bit to see if she thought it was funny.
Hasn’t been ruled out yet!
also anecdote time, but a buddy of mine is a small town, rural family Doc and his town is being hit for the first time. There were several massive 4th of July lake house parties and a bunch of infected high school and college kids (back in town for summer) spread it around, and then spread to families. Several of those adults work at the local nursing home.
The town has about 1500 people, and now there’s about ~100 confirmed positives from these parties and 10 Covid positive nursing home deaths, and several of them have been sudden, unexplained nursing home deaths in their sleep (probably clots or strokes if I had to guess).
anecdotal evidence but this is the nightmare scenario that isn’t hard to see happening.
Related to this, on July 4 I marked my calendar for today to see if any case spikes or hot spots are beginning to emerge. Based on your post it looks like there are places where the case spike probably began sooner if there are already deaths being reported.
Looks like Pfizer started it's Phase 3 yesterday too, along with Moderna. Interesting that they are moving forward for phase 3 with a different vaccine than the one they released pre-print results from earlier this month. It's a different mRNA that they think will cause less side effects.
Wait, people don’t know that I make medicine out of alien dna and that demon sperm causes endometriosis?
lol what simpletons you guys are. Sorry, snowflakes.