COVID-19 info thread

Discussion in 'The Mainboard' started by TrustyPatches, Mar 15, 2020.

  1. Illinihockey

    Illinihockey Well-Known Member
    Chicago CubsChicago BullsChicago BearsChicago BlackhawksIllinois Fightin' IlliniLiverpool

    Someone with a better grasp on things that I have, has the survivability of covid changed over time? I've seen articles not just about drug treatments but articles about how doctors hvae learned to treat covid turning patients over, when to put them on oxygen, when to put them on ventilators, how long to have people on oxygen, etc. Has this lowered the mortality for any age groups of the population as a whole?
     
  2. One Two

    One Two Send it!
    Donor
    Auburn TigersAtlanta Braves

  3. Henry Blake

    Henry Blake No Springsteen is leaving this house!
    Donor

  4. Uncle Tupelo

    Uncle Tupelo Well-Known Member
    Donor
    Ohio State BuckeyesCincinnati RedsCleveland Browns

    On the schedule for my first shot of the Pfizer phase 3 vaccine trial next week. A little nervous, but somebody's got to do it.
     
  5. RonBurgundy

    RonBurgundy Well-Known Member

    Tyfys
     
    rulethirty, IV, ZeroPointZero and 6 others like this.
  6. racer

    racer Yuma, where I work in software.
    Donor
    Iowa HawkeyesKansas City ChiefsLas Vegas Golden KnightsWatfordSneakersOlympicsTravel

    We nearly doubled yesterday from 800s to 1400 and doubled our positivity rate. Today jumped to 2500. Fuck Iowa.
     
  7. Pile Driving Miss Daisy

    Pile Driving Miss Daisy It angries up the blood
    Donor
    Texas LonghornsAtlanta BravesAtlanta HawksAtlanta FalconsAtlanta UnitedGeorgia Southern Eagles

    Do you know if Pfizer is also trying to recruit 30,000 people? Moderna seems to be close (if not already finished) getting enough people, but with two enormous phase 3 trials going on simultaneously, I wonder if Pfizer being slightly behind will have a harder time getting enough volunteers.
     
    Eamudo229 and One Two like this.
  8. Pile Driving Miss Daisy

    Pile Driving Miss Daisy It angries up the blood
    Donor
    Texas LonghornsAtlanta BravesAtlanta HawksAtlanta FalconsAtlanta UnitedGeorgia Southern Eagles

    I think there's at least four of us on the board who have said we're participating in trials, nice.
     
    slogan119, Henry Blake and One Two like this.
  9. Uncle Tupelo

    Uncle Tupelo Well-Known Member
    Donor
    Ohio State BuckeyesCincinnati RedsCleveland Browns

    From what I was told, they are trying to recruit 30,000 people as well. Not sure where they are in the enrollment process, but they seemed to have alot of slots open for the initial appointments. They were trying to get me in on Monday.

    I should also add that Moderna didn't have any trials in my city, so maybe Pfizer is adding sites in medium/small sized cites that Moderna didn't target.
     
    #7059 Uncle Tupelo, Aug 28, 2020
    Last edited: Aug 28, 2020
  10. Room 15

    Room 15 Mi equipo esta Los Tigres
    Donor
    Auburn TigersAtlanta BravesAtlanta FalconsAtlanta UnitedUnited States Men's National Soccer TeamLiverpool

    At one point Pfizer said they were looking at 120 sites globally, so they're hitting non-US markets as well.
     
  11. Pile Driving Miss Daisy

    Pile Driving Miss Daisy It angries up the blood
    Donor
    Texas LonghornsAtlanta BravesAtlanta HawksAtlanta FalconsAtlanta UnitedGeorgia Southern Eagles

    True, didn't think about that.
     
  12. Henry Blake

    Henry Blake No Springsteen is leaving this house!
    Donor

  13. One Two

    One Two Send it!
    Donor
    Auburn TigersAtlanta Braves



    I think pperc mentioned this pint earlier, where a vaccine could offer better immunity than a natural infection
     
    slogan119, pperc and Henry Blake like this.
  14. RonBurgundy

    RonBurgundy Well-Known Member

    this is common with many Preexisting vaccines hth
     
  15. One Two

    One Two Send it!
    Donor
    Auburn TigersAtlanta Braves

    Did not know that
     
    IV likes this.
  16. RonBurgundy

    RonBurgundy Well-Known Member

    Hib and pneumococcal are the 2 best examples along with tetanus and (you can absolutely argue) HPV.

    sometimes it requires multiple doses of the vaccine, like varicella, but at the end of the series, your vaccine immunity is equal or higher than the native infection
     
  17. pperc

    pperc Well-Known Member
    Donor

    yep. totally agree. if this wasn't true we couldn't develop vaccines against viruses that cause chronic infections like HPV.
    Hoping 1st gen vaccines have been thoughtful about utilizing conserves antigens. The nice thing about the mRNA vaccines is that they are super easy to change. I do believe the mAbs have been raised against conserved targets/sequences but we'll see.
     
  18. Room 15

    Room 15 Mi equipo esta Los Tigres
    Donor
    Auburn TigersAtlanta BravesAtlanta FalconsAtlanta UnitedUnited States Men's National Soccer TeamLiverpool

    What does conserved antigens mean?
     
  19. pperc

    pperc Well-Known Member
    Donor

    It means that between the different virus sequences some areas of that sequence are identical (i.e., conserved). Because they are conserved they product the same protein sequence in that particular area for that particular gene. That means antibodies against that part of the protein would cross react between the various viral strains.
     
    oldberg, BWC, Fargin' Icehole and 5 others like this.
  20. Room 15

    Room 15 Mi equipo esta Los Tigres
    Donor
    Auburn TigersAtlanta BravesAtlanta FalconsAtlanta UnitedUnited States Men's National Soccer TeamLiverpool

    certainly makes sense. What would be the reason for not doing it that way? Just lack of information?
     
  21. pperc

    pperc Well-Known Member
    Donor

    Yep, lack of information, impracticality, or impossibility.
     
    BWC and Room 15 like this.
  22. Imurhuckleberry

    Imurhuckleberry Avid spectator of windmill warriors
    Donor
    Florida GatorsSan Francisco GiantsGolden State WarriorsSan Francisco 49'ers

  23. BWC

    BWC It was the BOAT times, it was the WOAT times
    Donor
    Nebraska CornhuskersChicago CubsPittsburgh SteelersPittsburgh PenguinsNebraska Cornhuskers alt

    Woof at that title
     
    IV likes this.
  24. orangebl00d

    orangebl00d Six foot two and rude as hell
    Donor
    California Golden BearsTennessee VolunteersGolden State WarriorsGrateful Dead

    Newest right wing/QAnon/Trumper argument

     
  25. xec

    xec Well-Known Member
    Donor
    Florida State SeminolesUtah UtesReal Salt LakeLas Vegas Golden KnightsPorto

    Yeah. I’ve already responded to a couple of friends on FB. Basically said that in many viral and bacterial infections the deceased died of heart failure, pneumonia, paralysis, stroke, sepsis and other conditions caused by the virus. So they get co-listed with Covid-19 on the death certificate. The person would still be alive at the time of death if not for Covid-19, so it’s perfectly appropriate to call it a covid related death. I also pointed out that the CDC has tracked the Morbidity and Mortality of other viruses such as Influenza the exact same way for decades and it’s never been a problem.

    One of them replied, what about my friend who died in a motorcycle accident? I wrote, a competent ME wouldn’t co-list Covid-19 in that situation. But MEs are human and mistakes get made. I can see where State guidance could have confused a ME here and there early in the pandemic and they co-listed Covid to CYA. But these errors get cleaned up by the CDC in their review process.

    Haven't heard back, but I will...
     
    Doug, rulethirty, BWC and 1 other person like this.
  26. pperc

    pperc Well-Known Member
    Donor

    Hint: Their friend doesn’t exist.
     
  27. xec

    xec Well-Known Member
    Donor
    Florida State SeminolesUtah UtesReal Salt LakeLas Vegas Golden KnightsPorto

    Given that we are still learning about the virus, it makes sense to treat every possible case as if they can shed the virus imo. Also, a person with low virus load doesn’t necessarily maintain that low status, especially if the test caught the infection in its early stages. At the same time, the article makes clear that we need to be flexible and adjust as we learn.
     
    #7077 xec, Aug 30, 2020
    Last edited: Aug 30, 2020
  28. xec

    xec Well-Known Member
    Donor
    Florida State SeminolesUtah UtesReal Salt LakeLas Vegas Golden KnightsPorto

    Oh, I agree. Absolutely. But I have learned that in his case rational explanations are effective. I could point out that his friend is a Bot manufactured in Russia and he’s an idiot, but that would simply escalate the stupidity.
     
    Eamudo229, Doug, yaywaffles and 6 others like this.
  29. pperc

    pperc Well-Known Member
    Donor

    Or in the latter stages. Viral load is a function of time in an infection.
     
  30. xec

    xec Well-Known Member
    Donor
    Florida State SeminolesUtah UtesReal Salt LakeLas Vegas Golden KnightsPorto

    That’s true and if they can refine the tests to accurately assess the timing it will certainly help.
     
  31. Tiger Tiger Woods Y'all

    Tiger Tiger Woods Y'all Putting big balls in little holes, circa 1995
    Donor
    Clemson TigersGolden State WarriorsPGA

    The lack of smell/taste is pretty fucking weird. I can sense when things are sweet or salty or even spicy (a little bit) but everything is completely devoid of flavor. Going on at least a week so far.
     
    slogan119, ~ taylor ~ and xec like this.
  32. Pile Driving Miss Daisy

    Pile Driving Miss Daisy It angries up the blood
    Donor
    Texas LonghornsAtlanta BravesAtlanta HawksAtlanta FalconsAtlanta UnitedGeorgia Southern Eagles

    Not surprising given earlier info about church choirs being an example of where COVID has spread, but,

     
    ZeroPointZero, slogan119, xec and 4 others like this.
  33. DeToxRox

    DeToxRox (Insert name here) is tired - try again, Vin
    Staff Donor TMB OG
    Detroit PistonsDetroit LionsDetroit Red WingsWolverhampton WanderersDetroit Tigers

    Well, I passed my pre-screening call for the Pfizer trial with flying colors. I guess we’ll see where it goes.
     
  34. Fuzzy Zoeller

    Fuzzy Zoeller College football > NFL

    It was nice knowing you. Thank you for your sacrifice.
     
    buckwild, One Two, Doug and 3 others like this.
  35. tjosu

    tjosu This is kind of like the breakfast club, huh?
    Donor
    Oklahoma State CowboysHouston AstrosHouston TexansTiger Woods

    Looking for some input from uninvolved third parties if anyone cares to help out. Fiancée and I are currently trying to decide if we should postpone our wedding in Colorado on October 23. Relevant facts: looking at around 55-60 people; face masks and social distancing will be required and enforced by the venue (we’re also updating our website to inform everyone of all policies in place and telling people to abide by all guidelines); ceremony is under a covered patio, seating will be spaced 6 feet apart; dinner in the great room which is in the 3-4k square feet range, normally hosts weddings of 150-200 people easily; outdoor terrace is available all evening as well.

    Would you feel comfortable attending an event like this? Would you feel comfortable hosting the event? I think it can be hosted safely and responsibly, but that very much depends on everyone in attendance cooperating and being aware of all interactions throughout the night
     
  36. infected donkey

    infected donkey Arkansas Razorbacks
    Donor
    Arkansas RazorbacksChicago CubsAvengersBarAndGrillSoutheastern Conference

    Welp signed up for the vaccine trial, so lets see if I get selected.
     
    ZeroPointZero, slogan119, THF and 4 others like this.
  37. texasraider

    texasraider thanks
    Donor
    Texas RangersKansas City ChiefsTottenham HotspurDallas Mavericks altTexas Tech Red Raiders alt

    personally I'd feel very comfortable at the event because your policies have allowed me to act responsibly without depending on others.

    The only part that I would have an issue with would be flying to colorado.
     
  38. Redav

    Redav One big ocean
    Donor

    Seems pretty safe if you have compliance on masks and distancing. It's good that there's an outside area where people can distance as much as they like and it only being ~50 people
     
    One Two and tjosu like this.
  39. Redav

    Redav One big ocean
    Donor

    Does everyone live in the area? Would think traveling would be tricky
     
  40. RonBurgundy

    RonBurgundy Well-Known Member

    Just enrolled my first patient in our new outpatient monoclonal antibody study. Super excited they have an outpatient arm along with the inpatient arm. pperc
     
  41. tjosu

    tjosu This is kind of like the breakfast club, huh?
    Donor
    Oklahoma State CowboysHouston AstrosHouston TexansTiger Woods

    Travel is our biggest concern as many are not local. She has some family in NY that backed out a while ago due to the quarantine upon returning home. We have kicked around the idea of us getting tested prior to 1) confirm we’re negative and 2) maybe it’ll be a sign to everyone of how serious we are about following all policies
     
    One Two and Redav like this.
  42. JGator1

    JGator1 I'm the Michael Jordan of the industry
    TMB OG
    Florida GatorsTampa Bay RaysTampa Bay BuccaneersTampa Bay LightningChelsea

    If the cheap at home covid tests are available by that point then asking guests to get them wouldn't exactly be much of a burden.
     
    One Two and tjosu like this.
  43. xec

    xec Well-Known Member
    Donor
    Florida State SeminolesUtah UtesReal Salt LakeLas Vegas Golden KnightsPorto

    Personally I wouldn’t host it, nor would I attend. The dinner inside seems risky. The outdoors activities less so, but with 55-60 people there’s no way that distancing and masking will always be maintained. Will there be alcohol?
     
  44. tjosu

    tjosu This is kind of like the breakfast club, huh?
    Donor
    Oklahoma State CowboysHouston AstrosHouston TexansTiger Woods

    Yes to alcohol. We are aware that actually enforcing any of the policies is basically impossible, so we’re thinking of how to make it known what is expected and then also asking wedding party/family to police it a little bit as well. I get the concern with dinner for sure. Looking at our seating chart right now, most tables will have 6 people (a couple up to 8 with immediate family) and these will be spread out to utilize the entire room, so looking at maybe 20 foot gaps throughout the arrangement. We were able to have our tasting back in July and were very encouraged with the measures the staff were utilizing; never came close to us except to serve items, all were masked at all times, and they were clear that they’d be reminding people as well during the event
     
    xec likes this.
  45. pnk$krtcrÿnästÿ

    Donor
    Rutgers Scarlet KnightsArizona WildcatsTexas AandM Aggies altTennessee Volunteers

    Had three close friends with weddings slated for this summer/Fall. One is an ER doc who's one of my best friends from med school and he went all "lol fuck that" back in April, rescheduled for next summer. I told the other two that they should cancel for this year, and one of them did. The other pared it down to an outdoor only, 30 people occasion making a nice effort at social distancing but I'm not going.

    Look, you can line it all out so you have a safe appearing wedding on paper, but once there's 60 actual humans there, it becomes an absolute crapshoot. Indoors at sll is a bad idea. All 60 people have to be vigilant at all times. They won't. This is the reason weddings, family get togethers and funerals are one of the bigger spreaders in my state at present. Best laid plans n such.

    So no, I wouldn't feel comfortable coming if it were me. Many probably would, but shouldn't. Why not have your wedding in a year when you won't have a massive black cloud of uncertainty and anxiety looming over it? You deserve that. This reality really sucks and I feel for you guys.
     
    Eamudo229, slogan119, xec and 2 others like this.
  46. Lyrtch

    Lyrtch My second favorite meat is hamburger
    Staff Donor

    i'd just push it a year so it can be not really weird and potentially dangerous. most everyone i know with one scheduled this summer/fall already punted them.

    unless there's some dynamic where it really needs to happen for other reasons
     
    slogan119 and tjosu like this.
  47. Room 15

    Room 15 Mi equipo esta Los Tigres
    Donor
    Auburn TigersAtlanta BravesAtlanta FalconsAtlanta UnitedUnited States Men's National Soccer TeamLiverpool

    shotgun.gif

    I'll go on record as being pro-pre marital sex and I hope to have it one day
     
  48. tjosu

    tjosu This is kind of like the breakfast club, huh?
    Donor
    Oklahoma State CowboysHouston AstrosHouston TexansTiger Woods

    Thanks for the input. The bolded sentence is one that I’m struggling with because hopefully you’re right that everything will be better then, but who knows if that’ll be the case or not
     
  49. goblue31602

    goblue31602 Well-Known Member
    Donor
    Chicago BearsDetroit Red WingsTool

    Yeah we're going to a wedding next month in NC. My wife's cousin's daughter is getting married and my wife's cousin (whom she is very close with) is going to be lucky to even make it to the wedding, as she has already outlived her expectations with stage 4 cancer. She has lost a ton of weight recently and they are talking about possibly moving the wedding up if they can. My wife's dad is the officiant, and it's an outdoor ceremony. We're going to rent a house on a local lake and hang out for the weekend and just go to the ceremony (with masks, which are required) and then leave. We'll see her cousin (from a social distance) at other points in the weekend, but it will almost certainly be the last time we see her, if she even lives until then. Shitty situation, but not much we can do about it.
     
    slogan119, xec, pperc and 1 other person like this.
  50. tjosu

    tjosu This is kind of like the breakfast club, huh?
    Donor
    Oklahoma State CowboysHouston AstrosHouston TexansTiger Woods

    No kids in the plan any time soon. We both only have one grandma left and even though neither would be attending in person this year, I have some concern as to them both seeing the wedding next year as much as that sucks to say