COVID-19 info thread

Discussion in 'The Mainboard' started by TrustyPatches, Mar 15, 2020.

  1. Fargin' Icehole

    Fargin' Icehole 50% soulless
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  2. Uncle Tupelo

    Uncle Tupelo Well-Known Member
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    Doubt this is new news or anything, but the Dr. at my vaccine trial appt. (Pfizer) said they know the vaccine is well tolerated, and produces antibodies. The only question now is if those antibodies prevent infection, and how long they last. He said they will probably have an answer to the first question in about 4-6 months. Emergency authorization for healthcare workers and such may come in Nov.
     
  3. Pile Driving Miss Daisy

    Pile Driving Miss Daisy It angries up the blood
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    All of the big 3 vaccine makers (Pfizer, Moderna, AstraZeneca) have shown results that they produce antibodies and I believe all 3 have shown that there is a decent amount of antibodies even 3 months post inoculation. I know for Moderna this was a huge positive sign even in older patients. Pfizer and Moderna should hopefully have some efficacy results before the end of the year.
     
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  4. Room 15

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    Yea what sucks is they can prove safety a lot sooner than they can prove efficacy. They need enough placebo people to get infected.
     
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  5. RonBurgundy

    RonBurgundy Well-Known Member

    Haven’t been reading as much in the last 3 weeks being out with Covid myself, anyone have any good recent mask articles? I have a huge list of older studies but didn’t know if anything came out recently.
     
  6. Fargin' Icehole

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  7. Illinihockey

    Illinihockey Well-Known Member
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    So everything I'm seeing now is these vaccines won't prevent spread of the virus but will lessen symptoms. Did we know that? Is the goal to give this to at risk people and then say fuck it and let everyone else get sick?
     
  8. RonBurgundy

    RonBurgundy Well-Known Member

    Not true. It’s not like these vaccines are gonna work differently than literally every other vaccine in existence.
     
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  9. pperc

    pperc Well-Known Member
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    Idk what you replied to but it sounds stupid
     
  10. RonBurgundy

    RonBurgundy Well-Known Member

    The idea that vaccines won’t stop the spread but will lessen symptoms.
     
  11. pperc

    pperc Well-Known Member
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    Ah. Nothing is almost ever black and white. Probably going to be shades of grey on both metrics.
     
  12. Illinihockey

    Illinihockey Well-Known Member
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    https://www.dailymail.co.uk/news/ar...nes-prevent-symptoms-not-block-infection.html

    Dr Anthony Fauci has cautioned that early COVID-19 vaccines will be focused on preventing symptoms of the virus, not blocking it altogether.

    Fauci, the nation's leading expert on infectious diseases, made the point on Monday as at least four vaccine candidates near the end of clinical trials and the US reported a record number of new cases in the last week.

    While the end goal of the vaccines will be to eradicate the virus, Fauci noted that developers are aiming for a simpler goal in the first round of jabs.

    'The primary thing you want to do is that if people get infected, prevent them from getting sick, and if you prevent them from getting sick, you will ultimately prevent them from getting seriously ill,' Fauci said at Yahoo Finance's All Markets Summit.

    'If the vaccine also allows you to prevent initial infection, that would be great. [But] what I would settle for, and all of my colleagues would settle for, is the primary endpoint to prevent clinically recognizable disease.'

    Fauci's comments put a damper on America's hopes that forthcoming vaccines will bring the pandemic to its knees, highlighting the ongoing importance of other infection prevention methods like masks and social distancing.
     
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  13. RonBurgundy

    RonBurgundy Well-Known Member

    Sure, I think he’s just setting expectations. The goal of vaccination is to prevent initial infections, but even with influenza we know elders who get the vaccine usually have milder cases and less morbidity/complications than Those who don’t get it.
     
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  14. Room 15

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  15. Pile Driving Miss Daisy

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    There was a super huge tweet thread posted by some PhD that was shared here where a lot of the vaccines, thus far, have shown that they may prevent illness in the lungs but not fully in the upper respiratory tract and he suggested that may still allow spread. I'm assuming the flu vaccine is the same and that would still be hugely beneficial.
     
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  16. One Two

    One Two Send it!
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    Wouldn’t vaccines also theoretically reduce the contagious time frame for recipients?
     
  17. RonBurgundy

    RonBurgundy Well-Known Member

    Theoretically yes.
     
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  18. RonBurgundy

    RonBurgundy Well-Known Member

    Haven’t seen it. So apologies to Illinihockey if I’m way off on my responses. I know the goal is still to reduce transmission completely, but early vaccines are not going to be MMR-tier effective.
     
  19. pperc

    pperc Well-Known Member
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    correct. i think what we don't know here is impact on transmission of a vaccine. it's likely to lessen symptoms.
     
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  20. Pile Driving Miss Daisy

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    pperc Does this mean Pfizer thinks they'll have enough efficacy data to show if their vaccine is somewhat effective? Despite how fast they're working I'd be shocked if any of these manufacturers got enough data before close to the end of the yar.

     
  21. pperc

    pperc Well-Known Member
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    no it says they'll get safety data and then apply for EUA (frontline workers could get it, for example). I think full efficacy data may take time as you say. He tweeted this out as there has been a lot of chatter yesterday and today that this data is delayed and we should have already had it.
     
  22. Pile Driving Miss Daisy

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    Okay, I was under the impression that EUA required at least some efficacy data but I guess that's not correct.
     
  23. pperc

    pperc Well-Known Member
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  24. Pile Driving Miss Daisy

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    Awesome, thank you. I found this exact quote which means Moderna is probably pretty close to where they could apply for EUA based on having safety data.

     
  25. 1

    1 A real fan. GBR!
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    I just got accepted into the Novavax vaccine trial but it doesn't start for another couple weeks yet. For those that are following these things closely....should I get my affairs in order or how's this companies vaccine looked so far?
     
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  26. RonBurgundy

    RonBurgundy Well-Known Member

    Tyfys

    also RIP
     
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  27. pperc

    pperc Well-Known Member
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    you'll be fine... probably.
     
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  28. 1

    1 A real fan. GBR!
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    This is the confidence I come here for!
     
  29. Pile Driving Miss Daisy

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    Is it Phase 1/2 or Phase 3?
     
  30. AptosDuck

    AptosDuck Pedantic Hausfrau
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    You're more likely to die of something else during the trial
     
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  31. 1

    1 A real fan. GBR!
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  32. Pile Driving Miss Daisy

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  33. Room 15

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  34. pperc

    pperc Well-Known Member
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    We’ve discussed how shady that company is tho... at least the ceo is.
     
  35. pratyk

    pratyk Arsenal FC, Rutgers Scarlet Knights
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    You mean Moderna?
     
  36. Illinihockey

    Illinihockey Well-Known Member
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    If a couple of these vaccines get EUA by Thanksgiving, when could we see them start being distributed on a wider scale? Christmas? Middle of January?
     
  37. slogan119

    slogan119 Her?
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    For front line workers? Maybe.

    If everything goes well, probably April for the general population.

    Mentally, I’m preparing for Labor Day before the vaccine will be wide-spread enough to feel comfortable.
     
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  38. Pile Driving Miss Daisy

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    It would be nice if most of the older people could get vaccinated in the first couple of months in 2021. My 74 year old MIL had to move in with us because of how poorly she was doing when the assisted living facility she was in (in California) locked down, she's getting a lot worse with dementia that is likely Alzheimer's. It would be a huge weight off our shoulders if she could be one of the first of the general public to get vaccinated. I'm probably at one of the worst points in feeling depressed since I was a teenager right now, I have to sleep in the office room because my wife needs to sleep with her mother as she'll get up and start wandering or soil herself in the middle of the night.
     
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  39. pperc

    pperc Well-Known Member
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    no novavax
     
  40. pperc

    pperc Well-Known Member
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    brutal, im sorry.

    The AstraZeneca vaccine is the best shot at a vaccine working in the elderly, IMO
     
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  41. Illinihockey

    Illinihockey Well-Known Member
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    Thinking front line workers at 65+
     
  42. AptosDuck

    AptosDuck Pedantic Hausfrau
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    Aplologies if you've already addressed this, but do you foresee any kind of concerted effort to stack multiple vaccines together and give them to folks like the elderly who may not derive as much benefit from a single vaccine as younger people? Given that these different vaccines use different pathways, is it a good idea to offer them as a cocktail or sequentially to the elderly or the rest of the population in order to boost efficacy?
     
  43. pperc

    pperc Well-Known Member
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    that sort of clinical development would be an absolute nightmare, so in short, no way
     
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  44. RonBurgundy

    RonBurgundy Well-Known Member

    our plan is getting small supply of vaccines sometime between thanksgiving and christmas. First batch is allocated for ICU staff, ED staff, and LTC staff. Then next batches would go to patients 65+ and immunosuppressed/high risk. Then rest of employees. Then rest of patients. We don't expect much for volume of vaccinations until Spring/Summer or later.
     
  45. pperc

    pperc Well-Known Member
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    Why would you do this? Highly unlikely to be any data to support even immunogenicity in these patient populations for Pfizer / Moderna vaccines.
     
  46. RonBurgundy

    RonBurgundy Well-Known Member

    That was our ethics board decision. I’m sure if they haven’t/won’t be approved for those populations then we won’t give. Again, just the plan on paper right now.
     
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  47. Room 15

    Room 15 Mi equipo esta Los Tigres
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    Why / what does that mean?
     
  48. pperc

    pperc Well-Known Member
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    Vaccines tend to not work very well in the elderly
     
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  49. Chipper>Jeter

    Chipper>Jeter Defund the NCAA
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    Man that sucks hang in there.