Didn’t know that. Why is that other vaccine the best bet for elderly? Did all of these vaccines show antibody response in phase 1/2 for elderly?
no one has reported a large enough dataset in the elderly to be encouraging other than AstraZeneca, IMO. It technically makes sense due to how they are delivering their vaccine vs. the others but I don't want to go into the technical details
What about the Moderna data showing antibodies in the older participants after 3 months? I'm assuming that doesn't necessarily mean that they will still be protected?
I’m not thrilled with it only supposedly working in elderly at the 100ug dose and they didn’t report at the lower 25ug dose in the elderly. Adverse events at that higher dose are significant
yeah our leadership informed us that we may be getting vaccines for our frontline, covid patient-facing providers "sometime in mid November" and I have yet to understand how that's possible. No idea which vaccine it would be. Sure would like to before I get it
this is what the world looks like with "Yelp for drugs" as the FDA. It leaves it up to individuals and doctors to decide if a drug has merit and whether it should be used or not rather than having a reliable body to weigh the evidence and when approved doctors know it has met standards of effectiveness. the problem is individuals don't know shit (see: raging pandemic) and doctors don't have time to become experts in every fucking field.
This is way outside my professional lane but I think this drives at a separate concern w/ some COVID treatments/vaccines is that through greed/haste some ineffective stuff will get approved that significantly weakens the public's trust in getting vaccines or treatments that will exacerbate the pandemic. It's one thing to not do a thalidomide and another to promise some level of protection and then deliver.
I mean NNT is 25 to... avoid 1 hospitalization? And no mention of mortality benefit? And no change in viral load compared to placebo for most doses? thats garbage.
Yeah but if you're a mayo doc, you use your super special clinical clarevoyance to "just know that it works."
https://endpts.com/a-p-value-of-0-3...stions-for-eli-lillys-vaunted-covid-antibody/ this has good insight guys
guys... no words. FUCK. In a second big setback for Covid-19 antibody treatment hopes, Regeneron halts enrollment for more severe patients https://e.endpointsnews.com/t/t-l-xtkhyik-mklelrtu-u/
nothing is a silver bullet and some of the things i thought would be our best shots aren't even as averagely good as I hoped. we just don't really have the tools right now.
I have absolutely no medical training, but I feel like it's going to be really hard to do much to reverse this in patients who are already severe. Bad pneumonia seems hard to reverse, especially quickly, regardless of what's causing it. The article did say that they think it will do well as prophylaxis and help prevent people from getting severe symptoms, which I guess any positive is good at this point.
Do you think the key could be early intervention? Thinking out loud about Trump getting all that shit relatively early in the disease’s course
Of course early is better... but these are given IV guys. Do you think there enough hospital beds for those who don't require hospitalization for everywhere to sit there and get antibody infusions? there isn't nearly enough supply and the costs would be outrageous if you had to give to everyone. we can't predict who will become severe!
Did not realize the monoclonal antibodies were given via IV. Was hoping they were an injection like a vaccine lol
That's been my biggest isdue with trials focused on trying to prevent hospitalization/ED visits for patients with mild, early presentations. How in the fuck are outpatient clinics, most of which are understaffed and underresourced as it is, supposed to suddenly find a way to get tens of thousands of patients per day outpt IV infusions?
was just gonna post the remeron outpatient trial data which was.... again, positive but lackluster... their metric for improvement was no further need to medical appointments from an outpatient standpoint. our internal data is showing improvement in terms of recovery speed outpatient wise but pretty weak impact metrics so far... or at least what I’ve heard through the grapevine. I haven’t actually seen the data, just have patients who work on the research side
I was never as sold on antibody therapy as you guys. It didn’t make sense as a treatment for treatment of severe disease weeks after initial exposure and was always an impractical substitute for vaccination. It was always going to be public health measures that made the biggest difference until vaccines showed up. That’s still the case.
i had hopes that neutralizing active viral replication would allow the immune system a chance to move towards homeostasis
Our 5 year old is in contact tracing quarantine because a classmate tested positive. Last contact was Wednesday. Do we get him tested Saturday or Monday? He will stay in quarantine, just want to know for our families sake so we can isolate him if necessary.
WI hospitals starting to call in RNs from MN to staff excess beds. Seems like before you reach out to MN counties with 1/3rd of your covid incidence due to statewide mask mandate for help, your fucking gov't should start enforcing some infection control measures first.
Also, all our Twin Cities hospitals are getting filled up with outstate transfers. Hennepin county (Minneapolis and surrounding suburbs) and Ramsey (St. Paul) are 68th and 69th (out of 87 MN counties) respectively in new case incidence per capita, despite having by far the greatest pop density. Cases per 100k is certainly up in these counties, but not by a ton compared to August. It's all these fucking rural counties. Masks.
pperc the ethics board removed any patients from the vaccine distribution plan until more data is in btw, employees only on plan atm
https://www.abstractsonline.com/pp8/#!/9070/presentation/3855 For those who want to look at some detailed scientific analysis on risk factors for severe Covid-19
What are the best ways we should think about differentiating between a cold and covid as we get into the season? Nasal congestion, fever, ability to taste?
Was discussing with my work about planning for this. Part time workers can’t afford to quarantine for two weeks for the sniffles so trying to come up with a smarter way to handle it.
I only had nasal congestion and no fever. Doctor told me I probably just had a cold and was dead wrong. If you’re sick, stay the fuck home.