COVID-19 info thread

Discussion in 'The Mainboard' started by TrustyPatches, Mar 15, 2020.

  1. Room 15

    Room 15 Mi equipo esta Los Tigres
    Donor
    Auburn TigersAtlanta BravesAtlanta FalconsAtlanta UnitedUnited States Men's National Soccer TeamLiverpool

    Didn’t know that. Why is that other vaccine the best bet for elderly? Did all of these vaccines show antibody response in phase 1/2 for elderly?
     
  2. Illinihockey

    Illinihockey Well-Known Member
    Chicago CubsChicago BullsChicago BearsChicago BlackhawksIllinois Fightin' IlliniLiverpool

    Good to know we've all been waiting for a vaccine that won't actually help the people that need it.
     
  3. buckwild

    buckwild #BucketsGetsBuckets
    Donor
    Ohio State BuckeyesDetroit LionsDetroit PistonsDetroit Red Wings

     
    tjsblue, bertwing, oldberg and 6 others like this.
  4. pperc

    pperc Well-Known Member
    Donor

    no one has reported a large enough dataset in the elderly to be encouraging other than AstraZeneca, IMO. It technically makes sense due to how they are delivering their vaccine vs. the others but I don't want to go into the technical details
     
    Keef, oldberg, slogan119 and 2 others like this.
  5. pperc

    pperc Well-Known Member
    Donor

    thank you for posting that
     
    Keef and buckwild like this.
  6. Pile Driving Miss Daisy

    Pile Driving Miss Daisy It angries up the blood
    Donor
    Texas LonghornsAtlanta BravesAtlanta HawksAtlanta FalconsAtlanta UnitedGeorgia Southern Eagles

    What about the Moderna data showing antibodies in the older participants after 3 months? I'm assuming that doesn't necessarily mean that they will still be protected?
     
  7. pperc

    pperc Well-Known Member
    Donor

    I’m not thrilled with it only supposedly working in elderly at the 100ug dose and they didn’t report at the lower 25ug dose in the elderly. Adverse events at that higher dose are significant
     
  8. pnk$krtcrÿnästÿ

    Donor
    Rutgers Scarlet KnightsArizona WildcatsTexas AandM Aggies altTennessee Volunteers

    yeah our leadership informed us that we may be getting vaccines for our frontline, covid patient-facing providers "sometime in mid November" and I have yet to understand how that's possible.

    No idea which vaccine it would be. Sure would like to before I get it
     
    AlternativeFactsRule likes this.
  9. pperc

    pperc Well-Known Member
    Donor

    this is what the world looks like with "Yelp for drugs" as the FDA. It leaves it up to individuals and doctors to decide if a drug has merit and whether it should be used or not rather than having a reliable body to weigh the evidence and when approved doctors know it has met standards of effectiveness. the problem is individuals don't know shit (see: raging pandemic) and doctors don't have time to become experts in every fucking field.
     
  10. BleedinGreen

    BleedinGreen Detroit, Michigan State, and Celery
    Donor
    Detroit PistonsDetroit LionsMichigan State SpartansChelseaDetroit Red Wings

    This is way outside my professional lane but I think this drives at a separate concern w/ some COVID treatments/vaccines is that through greed/haste some ineffective stuff will get approved that significantly weakens the public's trust in getting vaccines or treatments that will exacerbate the pandemic. It's one thing to not do a thalidomide and another to promise some level of protection and then deliver.
     
  11. IV

    IV Freedom is the right of all sentient beings
    Donor TMB OG
    Alabama Crimson TideUAB BlazersDemocratAvengersBirmingham LegionUnited States Men's National Soccer Team

    Why not - most of America probably
     
  12. pperc

    pperc Well-Known Member
    Donor

    a good portion of the public wants Yelp for drugs
     
    BlazingRebel, AHebrewToo and IV like this.
  13. IV

    IV Freedom is the right of all sentient beings
    Donor TMB OG
    Alabama Crimson TideUAB BlazersDemocratAvengersBirmingham LegionUnited States Men's National Soccer Team

    I for one want to be able to buy cocaine legally on Beale Street again
     
    tjsblue, BlazingRebel, Keef and 4 others like this.
  14. RonBurgundy

    RonBurgundy Well-Known Member

    Well those are disappointing results. Definitely a positive trial but I expected bigger impact
     
  15. pperc

    pperc Well-Known Member
    Donor

    The Lilly mAb basically failed, fyi
     
  16. pnk$krtcrÿnästÿ

    Donor
    Rutgers Scarlet KnightsArizona WildcatsTexas AandM Aggies altTennessee Volunteers

    Hospitalized patients though, right?
     
  17. pperc

    pperc Well-Known Member
    Donor

    i don't remember exactly. just know their data has been tremendously disappointing
     
  18. RonBurgundy

    RonBurgundy Well-Known Member

    I mean NNT is 25 to... avoid 1 hospitalization? And no mention of mortality benefit? And no change in viral load compared to placebo for most doses?

    thats garbage.
     
    pperc likes this.
  19. pnk$krtcrÿnästÿ

    Donor
    Rutgers Scarlet KnightsArizona WildcatsTexas AandM Aggies altTennessee Volunteers

    Yeah but if you're a mayo doc, you use your super special clinical clarevoyance to "just know that it works."
     
  20. pnk$krtcrÿnästÿ

    Donor
    Rutgers Scarlet KnightsArizona WildcatsTexas AandM Aggies altTennessee Volunteers

  21. pperc

    pperc Well-Known Member
    Donor

    Henry Blake likes this.
  22. pperc

    pperc Well-Known Member
    Donor

    nothing is a silver bullet and some of the things i thought would be our best shots aren't even as averagely good as I hoped. we just don't really have the tools right now.
     
  23. goblue31602

    goblue31602 Well-Known Member
    Donor
    Chicago BearsDetroit Red WingsTool

    I have absolutely no medical training, but I feel like it's going to be really hard to do much to reverse this in patients who are already severe. Bad pneumonia seems hard to reverse, especially quickly, regardless of what's causing it. The article did say that they think it will do well as prophylaxis and help prevent people from getting severe symptoms, which I guess any positive is good at this point.
     
    AlternativeFactsRule likes this.
  24. One Two

    One Two Send it!
    Donor
    Auburn TigersAtlanta Braves

    Do you think the key could be early intervention? Thinking out loud about Trump getting all that shit relatively early in the disease’s course
     
  25. pperc

    pperc Well-Known Member
    Donor

    Of course early is better... but these are given IV guys. Do you think there enough hospital beds for those who don't require hospitalization for everywhere to sit there and get antibody infusions? there isn't nearly enough supply and the costs would be outrageous if you had to give to everyone. we can't predict who will become severe!
     
  26. One Two

    One Two Send it!
    Donor
    Auburn TigersAtlanta Braves

    Did not realize the monoclonal antibodies were given via IV. Was hoping they were an injection like a vaccine lol
     
  27. pnk$krtcrÿnästÿ

    Donor
    Rutgers Scarlet KnightsArizona WildcatsTexas AandM Aggies altTennessee Volunteers

    That's been my biggest isdue with trials focused on trying to prevent hospitalization/ED visits for patients with mild, early presentations. How in the fuck are outpatient clinics, most of which are understaffed and underresourced as it is, supposed to suddenly find a way to get tens of thousands of patients per day outpt IV infusions?
     
  28. RonBurgundy

    RonBurgundy Well-Known Member

    was just gonna post the remeron outpatient trial data which was.... again, positive but lackluster... their metric for improvement was no further need to medical appointments from an outpatient standpoint.

    our internal data is showing improvement in terms of recovery speed outpatient wise but pretty weak impact metrics so far... or at least what I’ve heard through the grapevine. I haven’t actually seen the data, just have patients who work on the research side
     
    oldberg, slogan119, xec and 2 others like this.
  29. AlternativeFactsRule

    AlternativeFactsRule Mmm ... Coconuts
    Donor TMB OG
    Michigan WolverinesSwansea

    I was never as sold on antibody therapy as you guys. It didn’t make sense as a treatment for treatment of severe disease weeks after initial exposure and was always an impractical substitute for vaccination. It was always going to be public health measures that made the biggest difference until vaccines showed up. That’s still the case.
     
    tjsblue likes this.
  30. pperc

    pperc Well-Known Member
    Donor

    i had hopes that neutralizing active viral replication would allow the immune system a chance to move towards homeostasis
     
    oldberg, BWC, slogan119 and 2 others like this.
  31. AHebrewToo

    AHebrewToo Albino Hebrew Extraordinaire
    Donor
    Indiana HoosiersNotre Dame Fighting IrishWashington NationalsIndiana PacersIndianapolis Colts

    Our 5 year old is in contact tracing quarantine because a classmate tested positive.

    Last contact was Wednesday. Do we get him tested Saturday or Monday? He will stay in quarantine, just want to know for our families sake so we can isolate him if necessary.
     
  32. pperc

    pperc Well-Known Member
    Donor

    either really should be OK, but wait until Monday if it's not a burden
     
    xec and AHebrewToo like this.
  33. DeToxRox

    DeToxRox Playing football during Covid is a bad idea imo
    Staff Donor TMB OG
    Detroit PistonsDetroit LionsDetroit Red WingsWolverhampton WanderersDetroit Tigers

  34. John McGuirk

    John McGuirk member of the blue tiger club
    Donor
    Auburn TigersAtlanta BravesDallas CowboysDallas StarsDallas Mavericks alt

    But Pawwl, that state ain’t got no money!!!
     
  35. pnk$krtcrÿnästÿ

    Donor
    Rutgers Scarlet KnightsArizona WildcatsTexas AandM Aggies altTennessee Volunteers

    WI hospitals starting to call in RNs from MN to staff excess beds.

    Seems like before you reach out to MN counties with 1/3rd of your covid incidence due to statewide mask mandate for help, your fucking gov't should start enforcing some infection control measures first.
     
  36. pnk$krtcrÿnästÿ

    Donor
    Rutgers Scarlet KnightsArizona WildcatsTexas AandM Aggies altTennessee Volunteers

    Also, all our Twin Cities hospitals are getting filled up with outstate transfers.

    Hennepin county (Minneapolis and surrounding suburbs) and Ramsey (St. Paul) are 68th and 69th (out of 87 MN counties) respectively in new case incidence per capita, despite having by far the greatest pop density. Cases per 100k is certainly up in these counties, but not by a ton compared to August.

    It's all these fucking rural counties.

    Masks.
     
  37. pperc

    pperc Well-Known Member
    Donor

    just say no?
     
    goblue31602 likes this.
  38. RonBurgundy

    RonBurgundy Well-Known Member

    pperc the ethics board removed any patients from the vaccine distribution plan until more data is in btw, employees only on plan atm
     
    pperc and AlternativeFactsRule like this.
  39. pperc

    pperc Well-Known Member
    Donor

    Makes sense
     
  40. pperc

    pperc Well-Known Member
    Donor

    BWC, shaolin5 and Fargin' Icehole like this.
  41. Room 15

    Room 15 Mi equipo esta Los Tigres
    Donor
    Auburn TigersAtlanta BravesAtlanta FalconsAtlanta UnitedUnited States Men's National Soccer TeamLiverpool

    What are the best ways we should think about differentiating between a cold and covid as we get into the season? Nasal congestion, fever, ability to taste?
     
  42. pperc

    pperc Well-Known Member
    Donor

    don't try. go get a test.
     
    tjsblue, shaolin5, Doug and 6 others like this.
  43. Room 15

    Room 15 Mi equipo esta Los Tigres
    Donor
    Auburn TigersAtlanta BravesAtlanta FalconsAtlanta UnitedUnited States Men's National Soccer TeamLiverpool

    And if it’s negative, believe it?
     
  44. pperc

    pperc Well-Known Member
    Donor

    Yes. But wear a mask and stay home if you're sick if you can :)
     
  45. Room 15

    Room 15 Mi equipo esta Los Tigres
    Donor
    Auburn TigersAtlanta BravesAtlanta FalconsAtlanta UnitedUnited States Men's National Soccer TeamLiverpool

    Was discussing with my work about planning for this. Part time workers can’t afford to quarantine for two weeks for the sniffles so trying to come up with a smarter way to handle it.
     
    One Two, lazy bum, BWC and 3 others like this.
  46. Arrec Bardwin

    Arrec Bardwin He ain’t me, he can’t be me
    Donor
    Auburn TigersAtlanta BravesAtlanta FalconsChelseaAtlanta United

    I only had nasal congestion and no fever. Doctor told me I probably just had a cold and was dead wrong.

    If you’re sick, stay the fuck home.