COVID-19 info thread

Discussion in 'The Mainboard' started by TrustyPatches, Mar 15, 2020.

  1. Arrec Bardwin

    Arrec Bardwin He ain’t me, he can’t be me
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    You don’t have a choice, if a doctor tells them to quarantine, you have to give paid leave and take a tax credit.

    https://www.jdsupra.com/legalnews/the-families-first-coronavirus-response-91845/
     
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  2. pperc

    pperc Well-Known Member
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    there isn't one. stay home if you're sick.
     
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  3. pperc

    pperc Well-Known Member
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  4. Room 15

    Room 15 Mi equipo esta Los Tigres
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  5. RonBurgundy

    RonBurgundy Well-Known Member

    “When Pfizer vaccination trial hospitalizations hit 34, they will unblind patients and if 26 are placebo and safety profile passes, they will apply for emergency use and then distribute. They are hoping soon. we will be on track to get our vaccination supply by mid December, 4k-20K doses.“

    pperc does that sound right?
     
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  6. pperc

    pperc Well-Known Member
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    yes it does
     
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  7. RonBurgundy

    RonBurgundy Well-Known Member

    That’s what I just heard in my surge plan meeting from one of our back end people, wanted to make sure it tracks. We are getting crushed and that’s literally the only good piece of information in the entire meeting.
     
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  8. pperc

    pperc Well-Known Member
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    i didn't check the exact numbers, but looks right
     
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  9. Room 15

    Room 15 Mi equipo esta Los Tigres
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    I understand it’s how it works but it makes me feel bad that I’m rooting for hospitalizations
     
  10. Fargin' Icehole

    Fargin' Icehole 50% soulless
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    Exclusive: WHO-led COVID drug scheme doubles down on antibodies, steroids and shuns remdesivir

    https://www.reuters.com/article/health-coronavirus-who-drugs-exclusive-i-idUSKBN27L1PE

    BRUSSELS (Reuters) - A World Health Organization-led scheme to supply COVID-19 drugs to poor countries is betting on experimental monoclonal antibody treatments and steroids but shunning Gilead's remdesivir therapy, an internal document shows.

    The Oct. 30 WHO draft document seen by Reuters says priorities are to secure monoclonal antibodies in a tight market and to boost distribution of cheap steroid dexamethasone, of which it has already booked nearly 3 million courses of treatment for poorer countries.

    Monoclonal antibodies are manufactured copies of antibodies created by the body to fight an infection, and drugmakers including Roche and Novartis confirmed initial contact with the WHO scheme.
    The paper, which for the first time outlines how the scheme would spend donors' money, does not cite remdesivir among priority drugs - a significant omission as the antiviral is the only other medication alongside dexamethasone approved across the world for treating COVID-19.

    Gilead Science said the WHO scheme had not funded its COVID-19 trials and had never approached the firm for the possible inclusion of remdesivir in its portfolio.

    The drug-supply scheme is one of the four pillars of the so-called ACT Accelerator, a WHO-led project which also seeks to secure COVID-19 vaccines, diagnostics and protective gear for poorer countries by raising more than $38 billion by the beginning of 2022.

    "Immediate priorities for the (therapeutics) pillar are intensifying efforts on monoclonal antibodies while scaling up dexamethasone use," says the document, which is subject to change but due for publication as soon as Friday.

    The scheme, co-led by the Wellcome Trust, a charity, and Unitaid, a health partnership hosted by the WHO, urgently needs $6.1 billion, $750 million of which by February, out of a total ask of $7.2 billion.

    More than half the cash would be used to procure and distribute monoclonal antibodies, the document shows, calling these therapeutics "game-changing" but in short supply.
    No monoclonal antibody has, so far, been approved against COVID-19, but the WHO scheme has already invested in research and secured production capacity at a Fujifilm Diosynth Biotechnologies plant in Denmark.

    Fujifilm didn't immediately comment.

    The scheme wants $320 million to make antibodies in that facility, the document says, estimating that would be enough to secure 4 million antibody courses, at about $80 per course.

    A spokeswoman for Unitaid confirmed that it wanted to raise and invest $320 million in securing monoclonal antibodies but said commercial deals were confidential.

    Another $110 million would be used for regulatory approval and other market preparation procedures for monoclonal antibodies in poorer countries, the document shows, while $220 million would fund clinical trials.
    Among companies developing experimental monoclonal antibodies against COVID-19 are U.S. firms Eli Lilly and Regeneron. U.S. President Donald Trump got their antibodies in October after testing COVID-19 positive.

    Eli Lilly has already agreed to produce antibodies at the Fujifilm plant from April and make them available at "an affordable price" to poorer countries, a company spokeswoman said. A U.S. government-run trial of Lilly's drug was paused in mid-October over safety concerns, but other trials continue and the U.S. administration last week sealed a $375-million supply deal.

    It is unclear how and whether the WHO scheme will raise the money needed for the antibody project.

    Roche, which has partnered with Regeneron to make up to 2 million doses of the so-called REGN-COV2 antibody annually by 2021, has had "preliminary discussions" with the ACT Accelerator over an access plan.

    "These discussions were in the context of development and production," a Roche spokesman said in an email. "It is too early to speculate on future decisions, but we will continue working with them and other groups regarding REGN-COV2." Novartis, which expects results soon from a trial of its arthritis treatment canakinumab against COVID-19, said on Thursday it received a request several days ago from the WHO scheme seeking information about medicines to tackle the coronavirus. Novartis also makes dexamethasone.



    Despite being short of funds, the WHO drugs-supply scheme aims to distribute hundreds of millions of courses of COVID-19 drugs to poorer countries by 2022.

    Apart from monoclonal antibodies and dexamethasone, it is also eyeing other experimental drugs, including new antivirals and repurposed drugs.

    The scheme would spend another $100 million to seal deals with unspecified drugmakers from mid-2021, the document says, and next year plans to invest another $4.4 billion on drugs that succeed in clinical trials.

    The Unitaid spokeswoman said dexamethasone and its alternative, hydrocortisone, were the most promising among repurposed drugs.

    Unitaid confirmed the scheme had not procured or funded remdesivir, which was initially trialled against Ebola. It did not comment on why remdesivir did not appear among priority treatments in the document. Remdesivir has been authorised in multiple countries to treat COVID-19. However, preliminary findings of a WHO-sponsored trial conluded the antiviral had little or no benefit, contradicting previous positive trials.

    Governments however continue to buy it, with Germany this week announcing a 150,000-plus dose purchase...
     
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  11. pperc

    pperc Well-Known Member
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    use of word scheme... gross
     
  12. Fargin' Icehole

    Fargin' Icehole 50% soulless
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    That was the word that pulled me into the article.
     
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  13. pperc

    pperc Well-Known Member
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    they gotcha.
     
  14. RonBurgundy

    RonBurgundy Well-Known Member

    Monoclonal antibodies have been disappointing so far. Steroids seem to work. Remdesivir definitely overrated and minimally effective.

    I volunteered to do hospital shifts starting in the next 1-2 weeks as that's when we'll start running over 100% normal capacity per all our models. We're in serious danger zone.
     
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  15. DeToxRox

    DeToxRox We dug coal together
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    This doesn’t sound ideal
     
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  16. One Two

    One Two Send it!
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    Nope. But if only 11 actual known infections not sure how we can definitively say it’s not more or less severe than the main strains?
     
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  17. It'sAlwaysSunnyInAthens

    It'sAlwaysSunnyInAthens Well-Known Member
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    My one year old doesn't go to daycare and is only ever around family. She had a fever and we took her to doctor. Negative for strep and doctor says she just has a virus. No one in the family is sick. Should I be concerned about covid?
     
  18. pperc

    pperc Well-Known Member
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    Your immediate family? Extended? And is your family a bunch of hermits that live in the woods?
    More seriously, yes it could be Covid. If she can catch another infection she can catch Covid. The fact that she is sick at all tells me someone she is around isn’t being careful. Keep your kid away from high risk individuals for the next 10 days.
     
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  19. It'sAlwaysSunnyInAthens

    It'sAlwaysSunnyInAthens Well-Known Member
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    Yea I didn't mean it wasn't possible she could pick something up. I was wondering if it was likely that she'd be the only one showing symptoms.
     
  20. pperc

    pperc Well-Known Member
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    It’s more than possible. Add the word “yet” to the end.
     
  21. pnk$krtcrÿnästÿ

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    Fuck that is some weak ass efficacy data
     
  22. pperc

    pperc Well-Known Member
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    It’s a relatively low bar. I think has good epi impact though.
     
  23. pnk$krtcrÿnästÿ

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    Gotta hope

    Was listening to the vaccine expert at CHOP who was hoping for 150 hospitalizations
     
  24. pperc

    pperc Well-Known Member
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    Paul? He is on fda vaccine adcom also
     
  25. slogan119

    slogan119 Her?
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    Have any of you heard if having Parkinson’s makes covid infection worse or more deadly?

    Prepping for a looming war with my SIL re: upcoming holiday plans.

    pperc pnk$krtcrÿnästÿ RonBurgundy
     
  26. pperc

    pperc Well-Known Member
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    I haven’t, sorry.
     
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  27. Jimmy Mac

    Jimmy Mac I can’t dance but I can throw the pill
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    Talked to a friend of mine yesterday and she was telling me about a friend of hers that’s developed a stutter since recovering from COVID. Going to go to the Cleveland clinic and see what they can do to help her, first time I’ve heard of this side effect.
     
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  28. pnk$krtcrÿnästÿ

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    Not specifically, no. Would think the age alone oughtta be a good enough point

    Edit, actually took a look in the lit quick. Looks like there are some small studies that indicate PD might be an independent risk factor for severity/mortality, but kinda has to do with severity if their PD
     
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  29. slogan119

    slogan119 Her?
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    Thanks. The age is a bigger concern IMO, but I know there will be a “They’re healthy!” comment.

    They’re already doing “pods” with some other families to swap out kids once in a while because the moms are going crazy. And then doing Thanksgiving w/ BIL’s parents next weekend.

    I’m not putting myself at risk for that shit when they could be doing what we are. Let alone bringing it to her mom’s house willingly.
     
  30. RonBurgundy

    RonBurgundy Well-Known Member

    I’m just cringing thinking about our state’s trajectory + thanksgiving and Christmas get togethers.

    bloodbath
     
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  31. xec

    xec Well-Known Member
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    Pretty much a national probability imo.
     
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  32. THF

    THF BITE THE NUTS, THUMB IN THE ASS!
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    Mortality I believe follows by about 27 days or so if I recall correctly. Should be right in time for Xmas. Really depressing to think about the impact this could have on some irresponsible families.
     
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  33. AlternativeFactsRule

    AlternativeFactsRule Mmm ... Coconuts
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    Or the impact this will have on responsible families because others weren’t.
     
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  34. infected donkey

    infected donkey Arkansas Razorbacks
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    We’re not doing anything with family this year, they’re all in the medical field but are being irresponsible as hell, yet they see this shit daily in the hospitals.
     
  35. Gunners

    Gunners Nicking a living
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    I’m proud of military base I work at: You’d expect Trumptards and a few don’t wear masks consistently but done well. Hope it continues
     
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  36. The Banks

    The Banks TMB's Alaskan
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    Dont forget peak flu season!
     
  37. Drew Swinney Esq

    Drew Swinney Esq You've gotta be on the team to get a ring.
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  38. pperc

    pperc Well-Known Member
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    ~ taylor ~, oldberg, One Two and 2 others like this.
  39. Pile Driving Miss Daisy

    Pile Driving Miss Daisy It angries up the blood
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    Edit: I read your thoughts in the other threads so I'm happy that your reaction is that this looks very positive.
     
    #7589 Pile Driving Miss Daisy, Nov 9, 2020
    Last edited: Nov 9, 2020
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  40. Fargin' Icehole

    Fargin' Icehole 50% soulless
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    Think he was commenting on lenzilumab
     
  41. pnk$krtcrÿnästÿ

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    Pfizer vacc seems like they're trying to keep their vaccine on the minds and mouths of people.

    90% effective at preventing symptomatic infection, which fairly impressive, but still a lot we don't know. And we know this vaccine presents large transport and storage dilemmas.

    But I'm not in a mood to be all cunty about those things today. This is a pretty incredible scientific milestone
     
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  42. Pile Driving Miss Daisy

    Pile Driving Miss Daisy It angries up the blood
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  43. Keef

    Keef Well-Known Member
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    He was talking about the second half of the post asking about lenzilumab
     
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  44. Pile Driving Miss Daisy

    Pile Driving Miss Daisy It angries up the blood
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    Are they the ones that require a -80C freezer for storage? Moderna is an mRNA vaccine as well which I think only requires minus -20C.
     
  45. Duval

    Duval On a gravy train with biscuit wheels
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    Good thread from someone who took the Pfizer trial vaccine.









     
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  46. pnk$krtcrÿnästÿ

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    Yep
     
  47. Pile Driving Miss Daisy

    Pile Driving Miss Daisy It angries up the blood
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    I mean because I'm in the Moderna trial and I'm being selfish, but I hope they have good efficacy data as well and get to market soon since it won't probably be quite as a logistical nightmare to store theirs.
     
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  48. Illinihockey

    Illinihockey Well-Known Member
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    So 50 mil doses this year and 1.3 billion in 2021. How will these be doled out? I think a lot of people assume most of the doses will just go to America which likely isn't the case.
     
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  49. Pile Driving Miss Daisy

    Pile Driving Miss Daisy It angries up the blood
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    Uhh, don't think that dude should really be putting that on blast considering he hasn't been unblinded and I doubt the researchers wanted him to speak publicly in that amount of detail.
     
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  50. pperc

    pperc Well-Known Member
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    this