COVID-19 info thread

Discussion in 'The Mainboard' started by TrustyPatches, Mar 15, 2020.

  1. RonBurgundy

    RonBurgundy Well-Known Member

    Yeah the data is really too sparse to really take down much and a total n = 1000 over many low quality studies isn’t exactly enough to make any definitive statements.

    I do think his point about anti-inflammatory properties is important, just like the pleiotrophic effects of other meds like statins and macrolides.

    a RR for mortality of .17 is fucking crazy though and 100% needs more studies. Even in early HCQ data it was modest impact and multiple negative studies existed from the outset.
     
  2. pperc

    pperc Well-Known Member
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    Sure, but anti-IL6's completely failed. So what inflammatory biomarker matters here? Shooting in the dark still.
    i think there are some really bad studies in these meta-analyses. We'll see.
     
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  3. RonBurgundy

    RonBurgundy Well-Known Member

    There are insanely bad studies in the meta analysis and they aren’t even peer reviewed. None of them are.
     
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  4. RonBurgundy

    RonBurgundy Well-Known Member

    Only Sith deal in absolutes. I need more data before I judge harshly.
     
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  5. pnk$krtcrÿnästÿ

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    also, what ever happened to this idea that coronaviruses mutate relatively slowly compared to, say, influenza? Or am I completely misremembering that?
     
  6. infected donkey

    infected donkey Arkansas Razorbacks
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    We don't know yet with these variants is all thats being put out.
     
  7. beerme

    beerme Well-Known Member
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    How about 13 million people got the vaccine so far, not one died. In that same time frame, about 13 million people got covid, and over 100,000 of them died
     
  8. pperc

    pperc Well-Known Member
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  9. THF

    THF BITE THE NUTS, THUMB IN THE ASS!
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    Would that mean someone who has been positive for Covid 19 potentially wouldn’t have immunity towards the South African version? I would think the antibodies or T cell memory operates around the spike as well and if the vaccine isn’t effective I would think antibodies wouldn’t either. Am I thinking incorrectly on this?
     
  10. JGator1

    JGator1 I'm the Michael Jordan of the industry
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    One or two people with a bad reaction to the shot will get a tweet from major news agencies the same the same way they'll tweet "3000 die from covid in 24 hours". Guess which one will get shared?
     
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  11. RonBurgundy

    RonBurgundy Well-Known Member

    Doing covid clinic today, old lady with copd “walked” in with an O2 sat of 62 fucking percent (presumably has Covid, test pending but she’ll be in a hospital bed before result is back).

    Holy fuck.
     
  12. pperc

    pperc Well-Known Member
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    The SA variant has enough changes in the spike that I need to see confirmatory data that vaccinated patient sera is still sufficiently able to neutralize virus. This work is being done now.
     
  13. Pile Driving Miss Daisy

    Pile Driving Miss Daisy It angries up the blood
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    In other news I just found out, despite being told differently (although i won't blame the Research Nurse) in early December, that the Moderna trial I'm in is only going to unblind and vaccinate people according to CDC guidelines. I'm guessing I won't get the chance to get it until mid to late February unless Georgia gets its shit together.
     
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  14. slogan119

    slogan119 Her?
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    I do not like this answer and want my displeasure on the record
     
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  15. Room 15

    Room 15 Mi equipo esta Los Tigres
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    That’s very different from what I heard just today. I expect a call later this week to schedule an appointment to come in and unblind. Maybe they turn around and say you’ll be available for appointment when your group is eligible, but that’s not what anyone is even remotely implying.
     
  16. Pile Driving Miss Daisy

    Pile Driving Miss Daisy It angries up the blood
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    This was based off a recording and was actually in the email (very innocuously at the bottom) they sent out saying we could be unblinded and vaccinated if we weren't. Hopefully you're right then, I haven't been able to get a hold of anyone and see what the deal is though.

    The good news is my wife said that her PCP is going to be able to vaccinate her mother with the first tomorrow though so now I'm not near as anxious as getting my dose.
     
  17. Room 15

    Room 15 Mi equipo esta Los Tigres
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    Shit I do see that blurb at the bottom that says they will prioritizing who the cdc calls at risk. It doesn’t necessarily say I will need to wait for my turn, just that they will prioritize the olds.

    bah humbug.
     
  18. Pile Driving Miss Daisy

    Pile Driving Miss Daisy It angries up the blood
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    Actually you're probably right, that may just mean that we could still get it soon but after everyone else in the trial group at each location.
     
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  19. One Two

    One Two Send it!
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    Judging from what numbers are doing in Alabama I’m guessing this has been circulating here longer than they think?

     
  20. IV

    IV Freedom is the right of all sentient beings
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    fuck
     
  21. pnk$krtcrÿnästÿ

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    Like demonic possession or some shit. Yeah, other week i had that healthy 30 year old gal you hear about with cough/sore throat/fatigue with a resting 02 of 78. No SOB at all
     
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  22. ramszoolander

    ramszoolander Ferrous and Fabulous
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    I am wondering if this hasn't been here for a while. I know a couple people that were exposed, tested positive, and another person who was only around them for about an hour and a half and was socially distanced caught it. The timetable is such that he almost certainly got it from that other group.
     
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  23. One Two

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    Sure but that’s a really long exposure time regardless of distance/indoor vs outdoor. I think high risk exposure is 15 minutes?
     
  24. Room 15

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    What’s normal?
     
  25. slogan119

    slogan119 Her?
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    95+ I think
     
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  26. goblue31602

    goblue31602 Well-Known Member
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    "Happy hypoxics" was the term they discussed a few months ago. Apparently the way this sits in your lungs, it doesn't stiffen them which causes SOB.
     
  27. pnk$krtcrÿnästÿ

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    haven't heard of "lung stiffness" causing shortness of breath. A low pO2 is typically detected by a number of chemoreceptors that feedback to the medulla, increasing respiratory rate and cardiac output, and generates the feeling of shortness of breath. Really anything that drops a person's O2 sat to 78% ought to trigger some sense of shortness of breath, really under any circumstance. Why that doesn't happen in covid, I don't have a good answer for.
     
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  28. Tigers

    Tigers Admin of the Year 2011-2014
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    Two questions and apologize if they are dumb:

    1. What makes the UK strain more contagious? Does it linger in the air longer? Smaller viral load to cause infection?

    2. COVID is bad because it is a new virus and therefore we have no natural immunity....right? Isn't that the cases with each person when they face any virus for the first time? Unless you got antibodies when you were an infant from mom your body would not have any natural immunity to anything? Just trying to better understand.
     
  29. goblue31602

    goblue31602 Well-Known Member
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    Two answers and I apologize to those who know more if they're dumb answers. And no, these are not dumb questions, these are questions I think we've all had since the beginning.

    1. I would assume a large part of this is still unknown, but could definitely be caused by the things you mentioned. Maybe it replicates quicker in the body.

    2. This is a novel virus, meaning it's the first of its kind after being transmitted from an animal. It is a coronavirus (just references the shape of the virus), and there are other coronaviruses out there, like the cold. This one acts very differently than those, and our bodies don't know how to fight if off. Other viruses usually act the same as their variants (flu strains, cold strains, etc) and so once our bodies have seen those types of viruses we have a gameplan to defend against them. Infants are very susceptible to illness, which is why they strongly suggest you don't kiss them or touch their faces. Also, that's why vaccines are out there for major illnesses as well as the flu, etc.

    Also on top of this being bad since we've never seen it, when it infects us it can cause a lot of damage. If we're infected with a regular cold we've never seen before, it's only going to do so much damage because it's just a cold. Covid-19 can be very severe which is why a vaccine is needed to help prevent severe infections.
     
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  30. pperc

    pperc Well-Known Member
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    1. I believe it achieves higher viral titers in the upper airway, but this is certainly an open question

    2. It's a new virus that infects many cell types and has a high rate of spread and fairly high CFR/IFR and seems to have significant morbidity as well (lots of hospitalizations). There is speculation that we may have some cross-immunity from infection with other coronaviruses but keep in mind that coronavirus immune responses wane over time. We have vaccines for many viruses that you will never be infected with in your lifetime because of that vaccine. Mothers pass antibodies to newborns through breastmilk but that is passive immunity and does not last beyond the period of breast feeding. The adaptive immune response is what generates antibodies and T-cells. That said, we have what's called innate immunity as well that is virus or bacteria agnostic. It kicks in first when you get an infection and before any adaptive immunity has formed. So, you do have "natural immunity" to pretty much everything. One hypothesis as to why Covid becomes so severe in some people is that your innate immunity goes into overdrive unleashing an immune "storm" on your body. It's why steroids are given as standard of care in severe Covid patients. Steroids reduce the immune response.
     
  31. Tigers

    Tigers Admin of the Year 2011-2014
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    thank you both- informative and helpful
     
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  32. pperc

    pperc Well-Known Member
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  33. RonBurgundy

    RonBurgundy Well-Known Member

    so hard to do though
     
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  34. pperc

    pperc Well-Known Member
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    Yes agreed.
     
  35. pperc

    pperc Well-Known Member
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    Rong thred
     
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  36. pratyk

    pratyk Arsenal FC, Rutgers Scarlet Knights
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    Pink bringing out the fury
     
  37. Gunners

    Gunners Nicking a living
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    Woke up with mild case on pink eye in 1 eye after a week plus visiting family
    If I get more symptoms, gonna just assume I have it
    If not, gonna get tested before going back to work on Monday

    I couldn’t care less about me, work with some vulnerable people so not gonna take chances.
     
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  38. Room 15

    Room 15 Mi equipo esta Los Tigres
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    Wait is pink eye a symptom?
     
  39. xec

    xec Well-Known Member
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    Yes
     
  40. xec

    xec Well-Known Member
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    If everyone had your attitude there would be many fewer deaths. :beerchug:
     
  41. Gunners

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    my thoughts this morning. Much better now but was pretty much blind in 1 eye, looked up COVID symptoms and conjunctivitis popped up.
     
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  42. Room 15

    Room 15 Mi equipo esta Los Tigres
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    I feel like I say this daily but...this fucking disease...
     
  43. pnk$krtcrÿnästÿ

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    pperc heard anything on the follow-up vaccine studies looking at preventing asymptomatic transmissibility?
     
  44. pnk$krtcrÿnästÿ

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    Yes I come to the tmb board dot com for my clinical learning
     
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  45. AlternativeFactsRule

    AlternativeFactsRule Mmm ... Coconuts
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    Can you get CME credits here?
     
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  46. pperc

    pperc Well-Known Member
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    nope, don't think they've announced any new data
     
  47. Hoss Bonaventure

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    Can’t remember which thread I posted in about my coworker currently being positive with mild to severe symptoms. Talked to him today and this is his second time to catch it. First time, last March or so, he had to get tested due to contact with person who tested positive. He tested positive and got the antibody test done and was positive but had no symptoms whatsoever. This time he said he’s just wrecked. Said he could barely walk to the bathroom, no smell/taste, cough everything. Had to go into ER for dehydration the other day. So wondering if this seems to be the case for people who catch it more than once?
     
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