Humanization of their immune system. Basically you genetically knock out their ability to make immune cells and replace their immune system with a fully human immune system. So all the immune cells are human, otherwise they are a mouse.
https://coronavirus.ohio.gov/wps/portal/gov/covid-19/dashboards/key-metrics/variants Not very thrilled about "other variants" muscling out delta in ohio
lol I’m getting all the vaccines. Got the flu one yesterday brought my daughters in to get their flu shots and ended up getting my shingles. My football team sucks but I am going to be invincible.
I have been trying to reach my boy Jose for about 1.5 weeks, no response. Jose is my guy that I can call for anything, work or home, and he will do it. He loves that green money and there is no task too degrading for him so long as it pays. Anyways, he finally texted me back this morning. Been laid up in his bedroom for 10 days with covid. Fuck. If he pulls through this, I am personally dragging his ass to get the vaccine.
Preprint https://www.biorxiv.org/content/10.1101/2021.09.30.462488v1 Our data demonstrate a substantial waning of antibody responses and T cell immunity to SARS-CoV-2 and its variants, at 6 months following the second immunization with the BNT162b2 vaccine. Notably, a significant proportion of vaccinees have neutralizing titers below the detection limit, and suggest a 3rd booster immunization might be warranted to enhance the antibody titers and T cell responses. Get boostied
i just got my booster super easy process. cvs didnt ask for any verification or anything. i even forgot my vax card and they told me no worries just bring it back later today so they can fill it out
did you walk in and ask? i just filled it out on the portal and said i was at high risk of exposure at work and no one asked to verify past that
The pharmacist at CVS told me to just say I was immunosuppressed in the registration and she would give it to me. She said the requirements are so broad/muddy that she doesn’t really care to audit.
yeah the portal gives you three options for why you qualify i think. age, health risk and exposure risk at work. i have yet to see any clear guidelines to what works qualify. i think its mainly teachers and food workers but my work is at 26% vaccinated so i think i qualify personally.
boostie was quick and easy at walgreens. just checked the box that i qualified and then got stuck didn’t experience the fever/chills like dose #2 but my arm was sore af. did not work out but i might after the new year
Is everyone boosting just Pfizer bros or is it for Moderna folks also? My parents are Moderna gang and convinced they can’t get it yet.
My parents are moderna and dad got his 3rd shot while mom insists on waiting for fda authorization even though she's antivax and only got vaxxed thanks to a ton of bargaining from the rest of us
Fucking hate this shit so much. 2 y/o still coughing some but overall seems to be dealing with it ok. It's hard to know since he got his flu shot right before this if his immune system is just really working overdrive- but he seems to still be happy and in good spirits so ill take that as a win. Not eating as much but keeping everything he drinks down. So that's good I guess but this thing is lingering. been a week now of symptoms. fever comes and goes. but now the wife is positive as of today. vaxxed so not really worried but can't describe how annoyed and defeated this feeling is. 4 y/o I think absorbed the energy of 100 additional suns though.
Have you smoked at anyooint in your life? Then eligible. You’re bmi>30, your eligible because of “underlying health issues”
Here was the guidance on the booster at sams club. Do i work with a large unvaxed contingency at work? Yes im saying I’m high risk of exposure. It’s vague for a reason.
Are there any guidelines for the J&J booster? Saw an earlier study that recommended after 6 months. I'm 6 months since J&J, wondering if I should just scheduled and get another. pperc
^I heard today that J&J is filing paperwork w the FDA to have a booster. No idea when it might be approved. https://archive.is/N3zQ7 Spoiler: NYTimes article WASHINGTON — Johnson & Johnson is planning to ask federal regulators early this week to authorize a booster shot of its coronavirus vaccine, according to officials familiar with the company’s plans. The firm is the last of the three federally authorized vaccine providers to call for extra injections, amid mounting evidence that at least the elderly and other high-risk groups need more protection. Federal officials have become increasingly worried that the more than 15 million Americans who received the Johnson & Johnson vaccine face too much risk of severe Covid-19. The Food and Drug Administration on Friday scheduled a meeting on Oct. 15 of its expert advisory committee to discuss whether to grant emergency use authorization of a booster shot of Johnson & Johnson’s vaccine. That is part of a broader effort by the government to shore up the protection provided by all three vaccines. Regulators last month authorized a booster shot for many recipients of Pfizer-BioNTech’s vaccine and are contemplating doing the same this month for recipients of Moderna’s. The fact that the advisory committee meeting on Johnson & Johnson was scheduled even before the company filed an application to the Food and Drug Administration reflects a particular sense of urgency in the Biden administration to provide more protection to recipients of that vaccine. a recent study by the Centers for Disease Control and Prevention found that Johnson & Johnson’s single-dose vaccine was only 71 percent effective against hospitalization from Covid-19, compared with 88 percent for Pfizer-BioNTech’s vaccine and 93 percent for Moderna’s. “Real-world data suggest that the two-dose Moderna and Pfizer-BioNTech mRNA vaccine regimens provide more protection” than the single dose of Johnson & Johnson, the researchers said. Other research found that Johnson & Johnson recipients were more likely to have breakthrough infections or symptomatic Covid-19 than recipients of the other two vaccines. Johnson & Johnson cites some studies with better results: A study of nearly two million people, funded by the company, estimated that the vaccine was 81 percent effective against hospitalization. Other research suggests that protection from Johnson & Johnson’s vaccine does not wane over time like protection from Pfizer-BioNTech’s vaccine. Nonetheless, Johnson & Johnson now appears to agree with federal officials that a single shot of its vaccine is not enough. Last month, the company announced that a second dose, given two months after the first, increased the vaccine’s effectiveness against symptomatic Covid-19 by about 22 percentage points, to 94 percent. The firm also said two shots were 100 percent effective against severe disease, although that estimate was less conclusive. because it required only one injection and was easier to transport. “It is rural areas that are getting particularly hit right now” by the Delta variant, Dr. Shah said. “So I think there is good reason to offer J. & J. recipients a booster if the data support it.” In San Francisco last month, health officials said Johnson & Johnson recipients would be permitted to receive a booster shot of either the Moderna or Pfizer vaccine. “If people talk to their health care provider and say, ‘I’d really like to have an mRNA shot in addition to the Johnson & Johnson shot that I got,’ we will accommodate that,” Dr. Grant Colfax, the city’s public health director, told reporters. Researchers found a nine- to twelvefold increase in antibodies among clinical trial recipients who received a second shot after six months, compared with a roughly fourfold increase for people who received a second dose after two months, Dr. Barouch said. But there could be a trade-off: Some argue that Johnson & Johnson recipients would not be sufficiently protected during the extra months before a second shot, and that a two-dose regimen made more sense from the start. The timing is not a trivial question: According to C.D.C. data, more than two-thirds of Johnson & Johnson recipients were vaccinated at least four months ago. Many would not be immediately eligible if a booster shot was available only six months after the first injection. The prospect of using a different vaccine as a booster presents another dilemma. A study by the National Institutes of Health suggests that Moderna’s vaccine works better as a booster than a second shot of Johnson & Johnson. But Dr. Barouch said that study only measured antibody levels — an indication of the strength of the immune system’s response — while Johnson & Johnson’s study of a second shot of its own vaccine looked at efficacy data. Johnson & Johnson is also considered likely to fight for using its own vaccine as a second shot to protect its public image. The company struggled for months with manufacturing problems that delayed delivery of tens of millions of doses it had promised to the federal government. And the vaccine’s appeal dropped after it was linked to a rare but serious blood-clotting disorder and injections were paused for 10 days in April. It remains a distant third in the number of shots administered in the United States. Moderna’s request for authorization of a booster shot is up next, with a meeting scheduled for Oct. 14, the day before the Johnson & Johnson discussion. Some experts suggest that the company’s supporting data is even more scant than Pfizer’s. Multiple studies indicate that the potency of Moderna’s vaccine wanes less over time than Pfizer’s. Moderna officials suggest that is because the dosage is stronger and the interval between shots is a week longer than in Pfizer’s regimen. On the other hand, the fact that the government has set a precedent in authorizing a Pfizer booster could generate momentum for extra shots of the other two vaccines. Otherwise, health care officials are left trying to explain why only Pfizer recipients are eligible for boosters. In Maine, for example, Dr. Shah said that health care staff who are administering booster injections are telling nursing home residents: “We’re really sorry, right now it’s only for those who got Pfizer, but don’t worry. Just because you’re not getting a booster today, does not mean your protection level has fallen to zero. We’ll be back, if and when” boosters of the other vaccines are cleared. “That’s a tough conversation to have,” he said. More support might come from Israeli health officials, who presented data last month at the Food and Drug Administration’s advisory committee hearing on a Pfizer booster. Israel has relied almost entirely on Pfizer’s vaccine. According to summaries of the country’s latest data, extra shots of Pfizer’s vaccine are associated with significantly lower rates of infection, severe Covid-19 and, among those 60 or older, death. At this point, federal officials and some of the government’s outside experts have accepted that they are making decisions with data that is less than perfect. As with the other vaccines, the data on Johnson & Johnson’s efficacy is fragmented and to some extent contradictory, discrepancies that may be at least partly explainable by whether the highly contagious Delta variant was dominant among the population being studied. “The data are somewhat all over the place,” Dr. Shah said. “That is the nature of science.” Noah Weiland contributed reporting.
Is the monoclonal antibody treatment thing legit? Wife is vaxxed but mild symtpoms (positive test) and just wondering if she should look into it to speed recovery. I never know what’s what when it comes to desantis endorsements. also since in heavily exposed I guess I’d be eligible for it too
He might live in Ron Desantis’s Florida where the state spends its money to fund Ron’s boosters to pass out the stuff in local libraries.