Pick two of these to start: Fred Jackson @ Mia, Reggie Bush @NYJ, Cedric Benson vs. CLE, Darren Sproles @ Pitt, or Thomas Jones vs. NO
Definitely go with Benson and then I think you take Jones over the others. The Saints have been tough against the run, but it's tough to know how the Bills are going to allocate carries between Lynch and Jackson this week.