One patient in DL 1 who received sLD developed COVID-19 pneumonia later died of complications of it, unrelated to ADI-001. While this is a very technical statement, just want everyone to remember that COVID-19 is killing vulnerable people. This person has cancer and was being treated. While they had very late stage cancer, it's still a tragedy. The treatment made their immune system weak, and then they died of COVID.
I'm not. Look at how much less neutralizing we are with the current vaccine vs. original strain. Going up 75% doesn't get us back to where we started. Not even close.
You think this is because they used the initial Omicron train that first hit hard last winter and now it's several generations more evolved, or is something more worrisome like the tech is hitting a plateau in what it can deliver in Ab level?
i think it's the former. strain has diverged substantially. BA1 infections don't protect well from BA2 .
Really seems like this is just going to keep happening for the indefinite future. Is there anything else they could do to speed up updating the vaccines? The actual changing of the mRNA I'm guessing is orders of magnitude quicker than what we had before, but doing even a quick Phase II clinical trial takes several months if they started this back in Janurary. Feels like the speed of the FDA and regulatory process were fine with dealing with influenza that doesn't mutate nearly as quick and vaccine makers needed to just manufacture enough for the fall/winter, but we're dealing with something that doesn't give a shit about how fast our processes move.
correct. vaccines can't be the only strategy. reminder though that we still get substantial protection from severe disease even with original vaccines.
I’ve been waiting on the 2nd booster in hopes of some more omicron specific boosters. Maybe that’s dumb but I wouldn’t want to get a current one that will impede my ability to get one of the more specific boosters when available.
i showed up at CVS since my mom was getting her 4th and I figured if I asked they would give it to me, they rejected me to my surprise
This was my understanding is that there wasn't a need for a fourth as of yet but that information is a couple months old
I’m going for #5 this weekend. Been about 4 months since shot four but I have a good deal of travel coming up soon so figured I’d get topped up a little early.
Shingles one of those weird things where I know next to nothing about it, have seen other people have it and like only recently realized I could get it at any moment. I think it's caused by stress???
It’s caused by the virus that causes chickenpox which lays dormant in your nerve roots after you’ve seemingly cleared it. Then when your immune system starts to slip, it flares up and causes a metric shit ton of pain. Get your shingles vaccine is what I’m saying.
I think we’re going with 50+ now, but it’s all going to be about what your insurance decides to cover. Because we live in hell and insurance is the devil.
50 I hit 50 four days ago and was planning to get my covid booster and Walgreen's asked me if I wanted the Shingles vax and I was like...
Anyone up to speed on status of intranasal Covid vaccines? Seem pretty promising based on article here
Nasal ones are more effective bc they are live vaccines, but that also limits who can get it (the vast majority of the population still can).
Dang we were really banking on the nebulous concept of freedom and sheep drench to protect our citizens
https://onlinelibrary.wiley.com/doi/10.1002/ana.26350 Neat but didn't know there was a mitochondrial interaction/infection. Finally something from my neck of the woods lol